Lorlatinib in Combination With Chemotherapy in Participants With Metastatic Anaplastic Lymphoma Kinase Positive (ALK+) Non-small Cell Lung Cancer (NSCLC) Who Progressed on Single-agent Lorlatinib

PHASE2WithdrawnINTERVENTIONAL
0
Timeline

Start Date

November 30, 2023

Primary Completion Date

March 31, 2025

Study Completion Date

September 30, 2025

Conditions
Lung CancerNon-small Cell Lung Cancer
Interventions
DRUG

Lorlatinib

Participants will receive assigned dose of daily oral lorlatinib continuously for each cycle. Each cycle is 3 weeks.

DRUG

Cisplatin or Carboplatin

Participants will receive standard of care intravenous Cisplatin or Carboplatin, both chemotherapy medications, on day 1 of each cycle every 3 weeks, for Cycles 1-4. Each cycle is 3 weeks.

DRUG

Pemetrexed

Participants will receive intravenous Pemetrexed, a chemotherapy medication, on day 1 of each cycle. Each cycle is 3 weeks.

Trial Locations (5)

23502

Virginia Oncology Associates, Norfolk

28806

Messino Cancer Center, Asheville

37203

Tennessee Oncology, Nashville

75246

Texas Oncology, Dallas

80218

Sarah Cannon Research Institute at HealthONE, Denver

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Pfizer

INDUSTRY

lead

SCRI Development Innovations, LLC

OTHER

NCT05948462 - Lorlatinib in Combination With Chemotherapy in Participants With Metastatic Anaplastic Lymphoma Kinase Positive (ALK+) Non-small Cell Lung Cancer (NSCLC) Who Progressed on Single-agent Lorlatinib | Biotech Hunter | Biotech Hunter