Testing the Combination of Two Anticancer Drugs M1774 (Tuvusertib) and Avelumab to Evaluate Their Safety and Effectiveness in Treating Merkel Cell Skin Cancer, MATRiX Trial

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

50

Participants

Timeline

Start Date

May 21, 2024

Primary Completion Date

January 1, 2028

Study Completion Date

January 1, 2028

Conditions
Clinical Stage III Cutaneous Merkel Cell Carcinoma AJCC v8Clinical Stage IV Cutaneous Merkel Cell Carcinoma AJCC v8Locally Advanced Merkel Cell CarcinomaMetastatic Merkel Cell CarcinomaRefractory Merkel Cell CarcinomaUnresectable Merkel Cell Carcinoma
Interventions
DRUG

Avelumab

Given IV

PROCEDURE

Biopsy Procedure

Undergo biopsy

PROCEDURE

Biospecimen Collection

Undergo collection of blood and stool

PROCEDURE

Computed Tomography

Undergo CT or PET/CT

PROCEDURE

Magnetic Resonance Imaging

Undergo MRI

PROCEDURE

Positron Emission Tomography

Undergo PET/CT

DRUG

Tuvusertib

Given PO

Trial Locations (52)

10016

Laura and Isaac Perlmutter Cancer Center at NYU Langone, New York

15232

University of Pittsburgh Cancer Institute (UPCI), Pittsburgh

20016

Sibley Memorial Hospital, Washington D.C.

21287

Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore

22908

University of Virginia Cancer Center, Charlottesville

23298

VCU Massey Comprehensive Cancer Center, Richmond

27157

Wake Forest University Health Sciences, Winston-Salem

30322

Emory University Hospital/Winship Cancer Institute, Atlanta

33136

University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami

33146

UM Sylvester Comprehensive Cancer Center at Coral Gables, Coral Gables

33176

UM Sylvester Comprehensive Cancer Center at Kendall, Miami

33180

UM Sylvester Comprehensive Cancer Center at Aventura, Aventura

33324

UM Sylvester Comprehensive Cancer Center at Plantation, Plantation

33442

UM Sylvester Comprehensive Cancer Center at Deerfield Beach, Deerfield Beach

33612

Moffitt Cancer Center - McKinley Campus, Tampa

Moffitt Cancer Center, Tampa

40536

University of Kentucky/Markey Cancer Center, Lexington

60611

Northwestern University, Chicago

62269

Memorial Hospital East, Shiloh

63110

Washington University School of Medicine, St Louis

63129

Siteman Cancer Center-South County, St Louis

63136

Siteman Cancer Center at Christian Hospital, St Louis

63141

Siteman Cancer Center at West County Hospital, Creve Coeur

63376

Siteman Cancer Center at Saint Peters Hospital, City of Saint Peters

64064

University of Kansas Cancer Center - Lee's Summit, Lee's Summit

64108

University Health Truman Medical Center, Kansas City

64154

University of Kansas Cancer Center - North, Kansas City

66044

Lawrence Memorial Hospital, Lawrence

66061

The University of Kansas Cancer Center - Olathe, Olathe

66160

University of Kansas Cancer Center, Kansas City

66205

University of Kansas Hospital-Westwood Cancer Center, Westwood

66210

University of Kansas Cancer Center-Overland Park, Overland Park

66211

University of Kansas Hospital-Indian Creek Campus, Overland Park

66606

University of Kansas Health System Saint Francis Campus, Topeka

67401

Salina Regional Health Center, Salina

67601

HaysMed, Hays

73104

University of Oklahoma Health Sciences Center, Oklahoma City

75390

UT Southwestern/Simmons Cancer Center-Dallas, Dallas

80045

UCHealth University of Colorado Hospital, Aurora

84112

Huntsman Cancer Institute/University of Utah, Salt Lake City

90020

Keck Medicine of USC Koreatown, Los Angeles

90033

Los Angeles General Medical Center, Los Angeles

USC / Norris Comprehensive Cancer Center, Los Angeles

92093

UC San Diego Moores Cancer Center, La Jolla

92612

UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care, Irvine

92663

USC Norris Oncology/Hematology-Newport Beach, Newport Beach

92868

UC Irvine Health/Chao Family Comprehensive Cancer Center, Orange

94304

Stanford Cancer Institute Palo Alto, Palo Alto

98109

Fred Hutchinson Cancer Center, Seattle

06520

Yale University, New Haven

02215

Dana-Farber Cancer Institute, Boston

M5G 2M9

University Health Network-Princess Margaret Hospital, Toronto

All Listed Sponsors
lead

National Cancer Institute (NCI)

NIH

NCT05947500 - Testing the Combination of Two Anticancer Drugs M1774 (Tuvusertib) and Avelumab to Evaluate Their Safety and Effectiveness in Treating Merkel Cell Skin Cancer, MATRiX Trial | Biotech Hunter | Biotech Hunter