Serotonin Control of Impulsivity in Tourette Disorder

PHASE2RecruitingINTERVENTIONAL
Enrollment

25

Participants

Timeline

Start Date

September 24, 2024

Primary Completion Date

September 24, 2027

Study Completion Date

September 24, 2028

Conditions
Tourette Disorder
Interventions
DRUG

Administration of a PET radiotracer

"A highly selective 5-HT2A receptor ligand (\[18F\]-altanserin) will be injected to patients before each PET scan. The IV injection in the arm (via a catheter) will be performed in continue during a period of 2 hours in the imaging centre (CERMEP) before the acquisition. The dose will be 2,6 MBq/kg +/- 10 % depending the prescription of the nuclear medicine.~Patients will be evaluated twice, one time free of neuroleptic treatment and a second time during stable chronic treatment by neuroleptic."

Trial Locations (2)

69677

RECRUITING

Service de neurologie C Hôpital neurologique Pierre Wertheimer/GHE Hospices Civils de Lyon, Bron

75013

NOT_YET_RECRUITING

Centre de Référence Syndrome Gilles de la Tourette Département de Neurologie Pôle des Maladies du Système Nerveux Hôpital de la Pitié-Salpêtrière, Paris

All Listed Sponsors
lead

Hospices Civils de Lyon

OTHER