Neoadjuvant Chemo-hypoRT Plus PD-1 Antibody (Tislelizumab) in Resectable LA-G/GEJ

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

21

Participants

Timeline

Start Date

June 10, 2023

Primary Completion Date

May 10, 2025

Study Completion Date

June 1, 2026

Conditions
Gastric or Gastroesophageal Junction Adenocarcinoma
Interventions
COMBINATION_PRODUCT

neoadjuvant chemo-hypofractionated radiotherapy plus PD-1 antibody (Tislelizumab)

"1. Immunotherapy combined with chemotherapy (2 cycles): Intravenous tislelizumab (200mg, d1, q21d) in combination with XELOX regimen (capecitabine 1000 mg/m2 bid\*14d + oxaliplatin 130mg/m2, d1, q21d);~2. Concurrent radiotherapy: Within one week after the first initiation of chemo-immunotherapy, concurrent hypofractionated radiotherapy will be started: intensity modulated radiotherapy was given for tumors, total dose:30Gy/12f, 2.5Gy/f."

Trial Locations (1)

210009

Jiangsu Cancer Hospital, Nanjing

All Listed Sponsors
lead

Jiangsu Cancer Institute & Hospital

OTHER