Sensitivity of Angiotensin II Type II Receptors in Women Following Preeclampsia

EARLY_PHASE1RecruitingINTERVENTIONAL
Enrollment

30

Participants

Timeline

Start Date

June 28, 2023

Primary Completion Date

August 12, 2025

Study Completion Date

June 1, 2026

Conditions
Preeclampsia Postpartum
Interventions
DRUG

Compound 21

"AT2R sensitivity: compound 21, and compound 21+ L-NAME (nitric oxide synthase inhibitor) are locally and acutely delivered to the cutaneous microvasculature to assess AT2R-mediated dilation and role of nitric oxide in this response~Local heating: compound 21 is locally and acutely delivered to the cutaneous microvasculature during local heating of the skin to assess endothelium-dependent dilation, L-NAME is added to assess nitric oxide-dependent dilation during this response"

Trial Locations (1)

52242

RECRUITING

University of Iowa, Iowa City

All Listed Sponsors
lead

Anna Stanhewicz, PhD

OTHER