NCT05935761View on ClinicalTrials.gov

Investigating Novel Interventions for Low Back Pain in US Military Veterans: A Randomized Controlled Adaptive Phase II Trial

PHASE2Not yet recruitingINTERVENTIONAL
Enrollment

108

Participants

Timeline

Start Date

October 1, 2025

Primary Completion Date

October 1, 2028

Study Completion Date

December 31, 2028

Conditions
Chronic Low Back Pain
Interventions
DRUG

Pregnenolone

Pregnenolone dosing will begin at 500mg/day x 7 days, and will increase by 500mg each following week as tolerated (to a potential maximum dose 2000mg/day).

DRUG

DHEA

DHEA dosing will begin at 100mg/day x 7 days, and will increase by 100mg each following week as tolerated (to a potential maximum dose 400mg/day).

DRUG

Placebo

Same as active comparator arms, except placebo dispensed

Trial Locations (1)

27705-3875

Durham VA Medical Center, Durham, NC, Durham

All Listed Sponsors
lead

VA Office of Research and Development

FED