Mutant KRAS G12V-specific TCR Transduced T Cell Therapy for Advanced Solid Tumor

PHASE1Not yet recruitingINTERVENTIONAL
Enrollment

11

Participants

Timeline

Start Date

July 31, 2023

Primary Completion Date

July 31, 2024

Study Completion Date

July 31, 2026

Conditions
Advanced Solid Tumor
Interventions
BIOLOGICAL

YK0901 cells

On day 0, the TCR-T cells will be administered one time. Drug: Fludarabine + Cyclophosphamide+Oxaliplatin Fludarabine: 25mg/m²/day×3days Cyclophosphamide: 300mg/m²/day×3 days Oxaliplatin:100mg×1day Drug: IL-2 After 18-24 hours of infusion of YK0901 cells, the patients will be given a small dose of IL-2 subcutaneously, 500,000 IU/time, twice a day (interval 10-12 hours), for 14 days.

Trial Locations (1)

Unknown

Department of GI Oncology, Peking University Cancer Hospital, Beijing

All Listed Sponsors
collaborator

Yingkai Saiwei(Beijing)Biotechnology Co., Ltd

UNKNOWN

lead

Peking University

OTHER

NCT05933668 - Mutant KRAS G12V-specific TCR Transduced T Cell Therapy for Advanced Solid Tumor | Biotech Hunter | Biotech Hunter