Outcomes of Aortic Dissection Repair

Enrolling by invitationOBSERVATIONAL
Enrollment

1,200

Participants

Timeline

Start Date

January 1, 2005

Primary Completion Date

December 30, 2021

Study Completion Date

December 31, 2025

Conditions
Type A Aortic DissectionAscending Aortic DissectionAortic DiseasesAortic ArchAortic Valve InsufficiencyAortic Root DissectionAortic Root DilatationType B Aortic Dissection
Interventions
PROCEDURE

Conservative Root- Sparing Aortic Valve Resuspension with or without Hemiarch Repair

Cardiac arrest will be performed by administering a potassium-rich antegrade cardioplegia solution delivered directly into the coronary ostium or in the case of aortic regurgitation after insertion of the coronary sinus cannula.The aorta will be resected up to the sinotubular junction and the thrombus located in the false lumen of the aortic root will be removed so that the aortic lesion can be visualized. The commissures will be resuspended using 4-0 or 5-0 sutures reinforced with a Teflon pledget above every commissure. A 4-0 or 5-0 polypropylene suture will be chosen to seal the proximal anastomosis and this suture line will also be used to secure the intima to the adventitia. In patients demonstrating normal-sized aortic roots associated with poor-quality valve leaflets, concomitant aortic valve replacement with conventional xenograft or mechanical prosthesis will be preferable.

PROCEDURE

Extensive Ascending Aorta Replacement (AAR) with Aortic Root Replacement (ARR)

Patients who experienced dilatation of the sinuses of Valsalva \> 4.5 cm in diameter on computed tomography imaging, those with connective tissue disease, or those in whom intimal tears extended into the sinuses, will receive replacement of the aortic root using a biologic or mechanical composite valve graft or valve-sparing root reimplantation procedure associated to AAR

PROCEDURE

Extensive Ascending Aorta Replacement (AAR) with Total Arch Replacement (TARP)

Total arch replacement procedures (TARP) will performed with the use of deep hypothermic circulatory arrest and with either antegrade or retrograde cerebral perfusion, maintaining systemic cooling between 19°C to 25°C and depending on the surgeon's practice.TARPs will be carried out using 1- and 4-branch grafts and involved the resection of all the aortic tissue up to the left common carotid artery (total arch)

PROCEDURE

Extensive Root and Ascending Aorta Replacement with Total Arch Replacement

This extensive procedure will include complete replacement of the anterior thoracic aorta extending to part or all of the aortic arch. It will be performed with the previously reported techniques

PROCEDURE

Thoracic Endovascular Aortic Repair

TEVAR patients have a higher incidence of complications and reintervention than open repair patients. TEVAR complications may include endoleak, retrograde type A aortic dissection, stent-graft migration, fracture or collapse, and increased size.

PROCEDURE

Open Thoracic Aortic Descendig Repair

Surveillance imaging can detect complications of open repair, such as graft infection and anastomotic pseudoaneurysm. After open repair or TEVAR, patients may develop progressive aneurysmal dilatation of adjacent or remote aortic segments.

Trial Locations (1)

93200

Francesco Nappi, Saint-Denis

All Listed Sponsors
collaborator

Henri Mondor University Hospital

OTHER

collaborator

Universita degli Studi di Genova

OTHER

collaborator

Pitié-Salpêtrière Hospital

OTHER

collaborator

Ospedale San Camillo, Rome, Italy

UNKNOWN

collaborator

Campus Bio-Medico University

OTHER

lead

Centre Cardiologique du Nord

OTHER