25
Participants
Start Date
July 31, 2023
Primary Completion Date
May 16, 2024
Study Completion Date
September 28, 2024
DZD9008 and Probe drugs (midazolam, digoxin, rosuvastatin)
Patients will receive single oral doses of probe drugs alone and after at least 27 days of treatment with DZD9008, 300 mg, once daily, until a treatment discontinuation criterion is met. Each patient will receive a single oral dose of DZD9008 on Day 7, and DZD9008 once daily for 27 days from Day 9 to Day 35. Patients will also receive a single oral dose of 2 mg midazolam on Day 1 and Day 32, and oral dose of 10 mg rosuvastatin and 0.25 mg digoxin cocktail on Day 2, Day 7 and Day 33.
Shandong Cancer Hospital (Shandong Provincial Institute of Cancer Prevention and Treatment), Jinan
Lead Sponsor
Dizal Pharmaceuticals
INDUSTRY