Study to Assess Neoadjuvant Durvalumab (D) and Platinum-Based Chemotherapy (CT), Followed by Either Surgery and Adjuvant D or CRT and Consolidation D, in Resectable or Borderline Resectable Stage IIB-IIIB NSCLC (MDT-BRIDGE)

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

142

Participants

Timeline

Start Date

February 22, 2024

Primary Completion Date

January 12, 2026

Study Completion Date

August 27, 2027

Conditions
Non-small Cell Lung Cancer
Interventions
DRUG

Durvalumab

Participants that go on to receive surgery, will receive durvalumab for up to four cycles prior to surgery. Participants that go on to receive CRT will receive durvalumab for up to two cycles prior to CRT. All participants will receive durvalumab every four weeks until disease progression or recurrence or up to 12 months following surgery/CRT, unless there is unacceptable toxicity, withdrawal of consent, or another discontinuation criterion is met.

Trial Locations (49)

1122

Research Site, Budapest

1130

Research Site, Vienna

1140

Research Site, Vienna

2045

Research Site, Törökbálint

10467

Research Site, The Bronx

12808

Research Site, Prague

13008

Research Site, Marseille

13125

Research Site, Berlin

20132

Research Site, Milan

20133

Research Site, Milan

20141

Research Site, Milan

22908

Research Site, Charlottesville

22927

Research Site, Großhansdorf

27100

Research Site, Pavia

28007

Research Site, Madrid

28027

Research Site, Madrid

28046

Research Site, Madrid

31008

Research Site, Pamplona

31059

Research Site, Toulouse

33604

Research Site, Pessac

34295

Research Site, Montpellier

37019

Research Site, Peschiera del Garda

38700

Research Site, La Tronche

40138

Research Site, Bologna

46009

Research Site, Valencia

47441

Research Site, Moers

48903

Research Site, Barakaldo

50009

Research Site, Zaragoza

51109

Research Site, Cologne

68070

Research Site, Mulhouse

70124

Research Site, Bari

75005

Research Site, Paris

77030

Research Site, Houston

77900

Research Site, Olomouc

80131

Research Site, Napoli

86000

Research Site, Poitiers

90127

Research Site, Palermo

97074

Research Site, Würzburg

K7L 2V7

Research Site, Kingston

G7H 5H6

Research Site, Chicoutimi

H4A 3J1

Research Site, Montreal

625 00

Research Site, Brno

150 06

Research Site, Prague

1350-352

Research Site, Lisbon

1500-650

Research Site, Lisbon

08025

Research Site, Barcelona

08908

Research Site, L'Hospitalet de Llobregat

171 64

Research Site, Solna

SE-751 85

Research Site, Uppsala

Sponsors

Lead Sponsor

All Listed Sponsors
lead

AstraZeneca

INDUSTRY