Variations in Ketone Metabolism

NARecruitingINTERVENTIONAL
Enrollment

400

Participants

Timeline

Start Date

June 20, 2023

Primary Completion Date

January 1, 2026

Study Completion Date

January 1, 2027

Conditions
Ketosis
Interventions
DIETARY_SUPPLEMENT

Ketone Supplement

Participants will be given 360mg/kg

BEHAVIORAL

Beverage Tolerability Questionnaire (BTQ) and satiety visual analogue scale

Beverage Tolerability Questionnaire (BTQ) and satiety visual analogue scale will be administered at beginning and end of testing day to tests palatability of supplement

BIOLOGICAL

Blood Draw

IV cannula will be inserted at the start of Test Day, and removed at the end of Test Day. Blood samples will be collected at 7 timepoints (possibly 1 more). Cannula will be flushed with a small volume of saline after each sample to maintain patency.

OTHER

Urine Analysis

Prior to consumption of the Study Product, participants will be asked to completely void bladder. And hydration status will be determined via urine specific gravity (USG) reporting \<1.025. Urine passed after the ingestion of the study product will be collected in a plastic container; participants will be asked to void their bladder and collect urine at the end of the test day. The volume produced will be recorded at the end of the study and aliquots will be frozen and stored for future analysis

Trial Locations (2)

43210

RECRUITING

The Ohio State University, Columbus

94945

RECRUITING

The Buck Institute, Novato

Sponsors
All Listed Sponsors
collaborator

Buck Institute for Research on Aging

OTHER

lead

Ohio State University

OTHER