FOG-001 in Locally Advanced or Metastatic Solid Tumors

PHASE1/PHASE2RecruitingINTERVENTIONAL
Enrollment

575

Participants

Timeline

Start Date

May 23, 2023

Primary Completion Date

April 1, 2027

Study Completion Date

August 31, 2027

Conditions
CancerColorectal CancerSolid TumorLocally Advanced Solid TumorMetastatic CancerWNT Pathwayβ-cateninBeta-cateninAdenomatous Polyposis ColiAPCHCCDesmoidMicrosatellite Stable Colorectal CancerMetastatic Castration-resistant Prostate CancerFAPEndometrial CarcinomaProstate CancerMicrosatellite Instability-High Colorectal CancerCTNNB1Adamantinomatous Craniopharyngioma
Interventions
DRUG

FOG-001

FOG-001 will be administered IV at assigned doses in continuous cycles of 28 days

DRUG

mFOLFOX-6

mFOLFOX-6 will be administered per the prescribing information in combination with FOG-001

DRUG

Nivolumab

Nivolumab will be administered per the prescribing information in combination with FOG-001

DRUG

Trifluridine/tipiracil

Trifluridine/tipiracil will be administered per the prescribing information in combination with FOG-001

DRUG

Bevacizumab

Bevacizumab will be administered per the prescribing information in combination with FOG-001

Trial Locations (16)

10065

RECRUITING

Memorial Sloan Kettering Cancer Center, New York

15232

RECRUITING

University of Pittsburgh Medical Center, Hillman Cancer Center, Pittsburgh

20016

RECRUITING

Johns Hopkins University, Sibley Memorial Hospital, Washington D.C.

21287

RECRUITING

Johns Hopkins University, The Sidney Kimmel Comprehensive Cancer Center, Baltimore

32746

RECRUITING

Florida Cancer Specialists, Lake Mary

37203

RECRUITING

Sarah Cannon Research Institute, Nashville

44106

RECRUITING

University Hospitals Cleveland Medical Center, Seidman Cancer Center, Cleveland

53705

RECRUITING

University of Wisconsin, Carbone Cancer Center, Madison

63110

RECRUITING

Washington University School of Medicine, St Louis

77030

RECRUITING

The University of Texas MD Anderson Cancer Center, Houston

78229

RECRUITING

South Texas Accelerated Research Therapeutics, LLC, San Antonio

85258

RECRUITING

Honor Health, Scottsdale

94304

RECRUITING

Stanford Cancer Institute, Stanford University, Palo Alto

97239

RECRUITING

Oregon Health and Science University, Portland

06520

RECRUITING

Yale University School of Medicine, New Haven

02114

RECRUITING

Massachusetts General Hospital, Boston

Sponsors
All Listed Sponsors
lead

Parabilis Medicines, Inc.

INDUSTRY

NCT05919264 - FOG-001 in Locally Advanced or Metastatic Solid Tumors | Biotech Hunter | Biotech Hunter