Clinical Study of Venetoclax Combined With CAG in the Treatment of Refractory/Relapsed Acute Myeloid Leukemia

PHASE2RecruitingINTERVENTIONAL
Enrollment

52

Participants

Timeline

Start Date

February 1, 2023

Primary Completion Date

December 31, 2024

Study Completion Date

December 31, 2025

Conditions
Acute Myeloid Leukemia
Interventions
DRUG

Ven+CAG

"100 mg on the first day, and then gradually increase to the target dose of 400 mg (100 mg d1, 200 mg d2, 400 mg d3) within 3 days; After that, the drug continued to be administered until the 14th day, 400 mg/day. When combined with CYP3A or P-gp inhibitors (mainly voriconazole in this study), adjust the venetoclax dose to 100 mg/day.~Ara-C 10mg/m2, ih, q12h × 14d; Acla 20mg/d × 4d; G-CSF 5ug/kg × 14d (WBC \> 30 × 10\^9/L pause)"

Trial Locations (1)

100044

RECRUITING

Peking University People's Hospital, Beijing

All Listed Sponsors
lead

Peking University People's Hospital

OTHER