Study Comparing the Efficacy of 2 RIC Regimens (Clofarabine vs Fludarabine) in Adults With AML Eligible to Allo-SCT

PHASE2RecruitingINTERVENTIONAL
Enrollment

302

Participants

Timeline

Start Date

September 14, 2023

Primary Completion Date

September 14, 2028

Study Completion Date

September 14, 2028

Conditions
Acute Myeloid Leukemia in Remission
Interventions
DRUG

Fludarabine

30 mg/m2/day IV fludarabine for 5 days (day-6 to day-2)

DRUG

Busulfan

130 mg/m2/day IV busulfan once daily for 2 days (day -4 and -3)

DRUG

ATG

Thymoglobuline®: 2.5 mg/Kg/day IV for 2 consecutive days (day -2 and -1)

DRUG

Clofarabine

30 mg/m2/day IV clofarabine for 5 days (day-6 to day-2)

Trial Locations (23)

44000

RECRUITING

CHU de Nantes, Nantes

Unknown

NOT_YET_RECRUITING

CHU Amiens, Amiens

RECRUITING

CHU Angers, Angers

NOT_YET_RECRUITING

CHU Besançon, Besançon

NOT_YET_RECRUITING

CHU Bordeaux, Bordeaux

RECRUITING

CHU Brest, Brest

RECRUITING

CRLC Caen, Caen

NOT_YET_RECRUITING

CHU Clermont-Ferrand, Clermont-Ferrand

NOT_YET_RECRUITING

APHP Créteil, Créteil

RECRUITING

CHU Grenoble, Grenoble

NOT_YET_RECRUITING

CHRU Lille, Lille

NOT_YET_RECRUITING

CHU Limoges, Limoges

NOT_YET_RECRUITING

CHU Lyon, Lyon

NOT_YET_RECRUITING

Institut Paoli Calmettes, Marseille

RECRUITING

CHU Montpellier, Montpellier

NOT_YET_RECRUITING

CHRU Nancy, Nancy

NOT_YET_RECRUITING

CHU Paris St-Louis, Paris

NOT_YET_RECRUITING

Pitie-Salpetriere, APHP, Paris

NOT_YET_RECRUITING

St-Antoine, APHP, Paris

NOT_YET_RECRUITING

CHU Poitiers, Poitiers

NOT_YET_RECRUITING

CHU Rennes, Rennes

NOT_YET_RECRUITING

CHU St-Etienne, Saint-Etienne

RECRUITING

CRLC Toulouse, Toulouse

All Listed Sponsors
lead

Nantes University Hospital

OTHER