Zanubrutinib Plus BR in Newly Diagnosed Symptomatic WM

PHASE2RecruitingINTERVENTIONAL
Enrollment

42

Participants

Timeline

Start Date

February 15, 2023

Primary Completion Date

March 15, 2025

Study Completion Date

December 15, 2025

Conditions
Waldenstrom Macroglobulinemia
Interventions
DRUG

Zanubrutinib, Bendamustine and Rituximab

Zanubrutinib, 160mg orally, twice a day; Bendamustine 70 mg/m2 on days 1 and 2 of each cycle; Rituximab (375 mg/m2 intravenously on day 0 of each cycle. ZBR was administered every 4 weeks for a total of 6 cycles, followed by maintenance therapy with zanubrutinib monotherapy for another 6 months.

Trial Locations (1)

300020

RECRUITING

Institute of Hematology & Blood Diseases Hospital, Tianjin

All Listed Sponsors
lead

Institute of Hematology & Blood Diseases Hospital, China

OTHER