A Study of IO102/IO103, Nivolumab, and Relatlimab in People With Melanoma

PHASE2RecruitingINTERVENTIONAL
Enrollment

43

Participants

Timeline

Start Date

June 9, 2023

Primary Completion Date

June 9, 2027

Study Completion Date

June 9, 2027

Conditions
Melanoma
Interventions
DRUG

IO102/IO103

IO102/IO103 will be administered subcutaneously on Days 1 and 15 of the first two 28-day cycles, and then on Day 1 only of subsequent cycles for two total years of treatment. Each vaccine contains 85ug.

DRUG

Nivolumab-Relatlimab

Nivolumab-relatlimab will be administered as a single infusion 160mg relatlimab and nivolumab 480 mg for all participants. Both agents will be combined in a single fixed-dose combination (FDC) as an intravenous 30-minute infusion every four weeks.

Trial Locations (9)

10065

RECRUITING

Memorial Sloan Kettering Cancer Center (All Protocol Activities), New York

10604

RECRUITING

Memorial Sloan Kettering Westchester (All Protocol Activities), Harrison

11553

RECRUITING

Memorial Sloan Kettering Nassau (Limited Protocol Activities), Uniondale

11725

RECRUITING

Memorial Sloan Kettering Suffolk - Commack (Limited Protocol Activities), Commack

18103

RECRUITING

Lehigh Valley Health Network (Data Collection Only), Allentown

06102

RECRUITING

Hartford Healthcare Alliance (Data Collection Only), Hartford

07920

RECRUITING

Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities), Basking Ridge

07748

RECRUITING

Memorial Sloan Kettering Monmouth (Limited Protocol Activities), Middletown

07645

RECRUITING

Memorial Sloan Kettering Bergen (Limited Protocol Activities), Montvale

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

IO Biotech

INDUSTRY

lead

Memorial Sloan Kettering Cancer Center

OTHER

NCT05912244 - A Study of IO102/IO103, Nivolumab, and Relatlimab in People With Melanoma | Biotech Hunter | Biotech Hunter