Abequolixron (RGX-104) and Durvalumab in Lung Cancer

1,500 mg Durvalumab IV infusion will be given on day 1 of each cycle for 3 cycles.

Carboplatin IV infusion will be given on day 1 of each cycle for 3 cycles. The dose will be AUC 5.

100 or 120 mg Abequolixron will be administered by mouth twice a day for 5 days followed by 2 days off throughout your treatment (5 days a week for up to 9 weeks).

100 mg/m2 Abraxane will be given by IV infusion on days 1, 8, and 15 of each cycle for 3 cycles.

500 mg/m2 pemetrexed will be given by IV infusion on day 1 of each cycle for 3 cycles.