190
Participants
Start Date
September 19, 2023
Primary Completion Date
December 27, 2026
Study Completion Date
December 27, 2026
Change of antimicrobials based on BCID2 and Reveal Rapid AST tests. Stop of antimicrobials based on PCT results.
After the patient's blood flask is flagged positive for bloodstream infection, the blood sample will be assessed in the BCID2 diagnostic test in order to identify the underlying pathogens the patient is infected with. After the identification, and in the presence of gram-negative bacteria, the sample will be assessed in the Reveal Rapid AST test to provide information about which antimicrobials the specific pathogens are sensitive to. When both the identification of the pathogen and the sensitivities are available, the central laboratory will inform the attending physicians, who are obliged to change the standard of care antimicrobial therapy administered based on the rule in Box1 of the protocol. Finally, based on the results of the procalcitonin (PCT) on the first day by day 5 when PCT value is less than 80% of the initial value or it remains below 0.5 ng/ml, the attending physicians should discontinue the antimicrobial therapy.
Standard of Care
Standard of care practices of the specific study site. Antimicrobials will be administered based on the attending physicians' critical opinion, and discontinuation will be done based on the standard procedures of the study site.
RECRUITING
1st Department of Internal Medicine, General Hospital of Athens KORGIALENIO-BENAKIO E.E.S., Athens
RECRUITING
Intensive Care Unit of Center for Respiratory Failure, Sotiria Chest Diseases Athens General Hospital, Athens
RECRUITING
New Multivalent Intensive Care Unit, Sotiria Chest Diseases Athens General Hospital, Athens
RECRUITING
1st Department of Internal Medicine- General Hospital of Athens GENNIMATAS, Athens
RECRUITING
3rd University Department of Internal Medicine, Sotiria Athens General Hospital, Athens
RECRUITING
2nd Propaedeutic Department of Internal Medicine, Attikon University Hospital, Athens
RECRUITING
4th Department of Internal Medicine, Attikon University Hospital, Athens
RECRUITING
Clinic of Intensive Care and Pulmonary Diseases, Aghioi Anargyroi Kifissia General Oncologic Hospital, Kifissia
NOT_YET_RECRUITING
1st Department of Internal Medicine - General Hospital of Athens Sismanoglio- Amalia Fleming, Athens
RECRUITING
"3rd Department of Internal Medicine - General State Hospital of Nikaia Saint Panteleimon - West Attica General Hospital Agia Varvara", Athens
RECRUITING
"2nd Department of Internal Medicine, General Hospital of Piraeus Tzaneio", Piraeus
RECRUITING
"1st Department of Internal Medicine, General Hospital of Elefsina Thriasio", Athens
NOT_YET_RECRUITING
1st University Department of Internal Medicine, AHEPA University General Hospital of Thessaloniki, Thessaloniki
NOT_YET_RECRUITING
Intensive Care Unit, Ippokrateion General Hospital, Thessaloniki
NOT_YET_RECRUITING
2nd Department of Internal Medicine, University General Hospital of Alexandroupolis, Alexandroupoli
Hellenic Institute for the Study of Sepsis
OTHER