A Study of Vepdegestrant (ARV-471, PF-07850327) Plus Palbociclib Versus Letrozole Plus Palbociclib in Participants With Estrogen Receptor Positive, Human Epidermal Growth Factor Negative Advanced Breast Cancer

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

59

Participants

Timeline

Start Date

August 9, 2023

Primary Completion Date

December 30, 2026

Study Completion Date

December 30, 2026

Conditions
Breast Cancer
Interventions
DRUG

ARV-471 (PF-07850327)

Pharmaceutical form: Tablets. Route of Administration: Oral

COMBINATION_PRODUCT

Palbociclib

Pharmaceutical form: Capsules. Route of Administration: Oral.

DRUG

Letrozole

Pharmaceutical form: Capsules. Route of Administration: Orally

COMBINATION_PRODUCT

Palbociclib

Pharmaceutical form: Capsules. Route of Administration: Oral.

Trial Locations (28)

3220

Barwon Health, Geelong

5000

Cancer Research SA, Adelaide

Tumor Zentrum Aarau, Aarau

18012

Hospital Unviersitario Virgen Nieves, Granada

20900

Fondazione IRCCS San Gerardo dei Tintori, Monza

23007

Complejo Hospitalario de Jaén, Jaén

23502

Virginia Oncology Associates, Norfolk

28040

Hospital Clinico San Carlos, Madrid

29010

Hospital Universitario Virgen de la Victoria, Málaga

33322

BRCR Medical Center Inc, Plantation

47014

"IRCCS - Istituto Romagnolo per lo Studio dei Tumori (IRST) Dino Amadori", Meldola

80131

Istituto Nazionale Tumori IRCCS Fondazione Pascale, Napoli

95801

Nemocnica na okraji mesta n o, Partizánske

100021

Cancer Hospital Chinese Academy of Medical Science, Beijing

430079

Hubei Cancer Hospital, Wuhan

510060

Sun Yat-sen University Cancer Center, Guangzhou

710061

The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an

29043-260

Hospital Santa Rita de Cassia, Vitória

90110-270

Centro Gaucho Integrado De Oncologia, Hematologia, Ensino E Pesquisa, Porto Alegre

90850-170

Centro de Pesquisa Clínica - Área Administrativa, Porto Alegre

90880-480

Hospital Mae de Deus, Porto Alegre

04032

Debreceni Egyetem Klinikai Kozpont, Debrecen

464-8681

Aichi Cancer Center Hospital, Nagoya

277-8577

National Cancer Center Hospital East, Kashiwa

104-0045

National Cancer Center Hospital, Chuo-ku

080 01

Fakultna nemocnica s poliklinikou J.A. Reimana Presov, Prešov

08916

Institut Català d'Oncologia (ICO) - Badalona, Badalona

08028

Hospital Universitari Dexeus, Barcelona

Sponsors

Lead Sponsor

All Listed Sponsors
collaborator

Arvinas Estrogen Receptor, Inc.

INDUSTRY

lead

Pfizer

INDUSTRY

NCT05909397 - A Study of Vepdegestrant (ARV-471, PF-07850327) Plus Palbociclib Versus Letrozole Plus Palbociclib in Participants With Estrogen Receptor Positive, Human Epidermal Growth Factor Negative Advanced Breast Cancer | Biotech Hunter | Biotech Hunter