Clinical Study Protocol of Maintenance Therapy With Venetoclax in Elderly Patients With AML in First Complete Remission

NARecruitingINTERVENTIONAL
Enrollment

100

Participants

Timeline

Start Date

April 12, 2023

Primary Completion Date

May 30, 2025

Study Completion Date

May 30, 2028

Conditions
Acute Myeloid Leukemia
Interventions
DRUG

Venclexta 100 MG Oral Tablet

"When there is a deficiency of neutrophils, G-CSF treatment may be necessary. The treatment is continued until the absolute neutrophil count (ANC) reaches either \>0.5×109/L and remains at that level for 3 consecutive days, or \>2×109/L. The purpose of G-CSF therapy in this context is to stimulate the production of neutrophils and restore their levels to a sufficient and stable range. This helps to strengthen the immune system and reduce the risk of infections associated with low neutrophil counts.~When experiencing Grade 3-4 thrombocytopenia, subcutaneous injection of IL-11 can be administered as a treatment.~When symptoms of infection occur, aggressive antimicrobial therapy and other supportive treatments should be administered.~All blood products should undergo irradiation when transfused, and all blood products must be filtered before infusion.~If gastrointestinal adverse reactions occur, antiemetic medications can be administered to alleviate symptoms."

Trial Locations (1)

210000

RECRUITING

The First Affiliated Hospital with Nanjing Medical University, Nanjing

All Listed Sponsors
collaborator

Huai'an First People's Hospital

OTHER

collaborator

Yancheng First People's Hospital

OTHER

lead

The First Affiliated Hospital with Nanjing Medical University

OTHER

NCT05909293 - Clinical Study Protocol of Maintenance Therapy With Venetoclax in Elderly Patients With AML in First Complete Remission | Biotech Hunter | Biotech Hunter