Decitabine for Poor Graft Function Post Allo-HSCT

PHASE3Not yet recruitingINTERVENTIONAL
Enrollment

76

Participants

Timeline

Start Date

July 1, 2023

Primary Completion Date

July 1, 2026

Study Completion Date

November 1, 2026

Conditions
Poor Graft Function
Interventions
DRUG

Decitabine

Decitabine 6 mg/m2 daily subcutaneously for consecutive 3 days (day 1 to day 3)

DRUG

Granulocyte Colony-Stimulating Factor

5ug/kg/d when absolute neutrophil count ≤ 1.5 × 109/L

DRUG

Thrombopoietin Receptor Agonist

Eltrombopag initial dose: 25 mg orally once a day, may increase to up to 75 mg/day, when platelet count ≤ 30 × 109/L; Avatrombopag initial dose: 20 mg orally once a day, may increase to up to 60 mg/day, when platelet count ≤ 30 × 109/L.

DRUG

Recombinant human erythropoietin

10000 U/day when hemoglobin ≤ 85 g/L

All Listed Sponsors
lead

The First Affiliated Hospital of Soochow University

OTHER

NCT05907499 - Decitabine for Poor Graft Function Post Allo-HSCT | Biotech Hunter | Biotech Hunter