A Study to Assess Naporafenib (ERAS-254) Administered With Trametinib in Patients With RAS Q61X Mutations

PHASE1Active, not recruitingINTERVENTIONAL
Enrollment

86

Participants

Timeline

Start Date

August 17, 2023

Primary Completion Date

July 31, 2025

Study Completion Date

November 30, 2025

Conditions
Advanced or Metastatic Solid Tumors
Interventions
DRUG

Naporafenib

Naporafenib (ERAS-254) 200 mg twice daily (BID) of an experimental Pan-Raf inhibitor

DRUG

Trametinib

Trametinib is an FDA approved anticancer medication that targets MEK1 and MEK2.

Trial Locations (29)

22031

Inova Schar Cancer Institute, Fairfax

NEXT Virginia, Fairfax

30322

Emory University School of Medicine, Atlanta

33705

Florida Cancer Specialists - St. Petersburg, St. Petersburg

34232

Florida Cancer Specialists - Sarasota, Sarasota

37203

SCRI Oncology Partners (formerly Tennessee Oncology), Nashville

48108

Inje University Haeundae Paik Hospital, Busan

48202

Henry Ford Health System, Detroit

53792

University of Wisconsin, Madison

63110

Washington University School of Medicine, St Louis

77030

The University of Texas MD Anderson Cancer Center, Houston

89169

Comprehensive Cancer Center of Nevada (CCCN), Las Vegas

94143

University of California, San Francisco, San Francisco

97239

Oregon Health & Science University, Portland

06510

Yale Cancer Center, New Haven

Unknown

Macquarie University, Macquarie Park

St. Vincent's Hospital, Melbourne

Linear Clinical Research, LTD, Perth

London Regional Cancer Center, London

National Cancer Center, Goyang-si

Seoul National University Hospital Bundang, Gyeonggi-do

Seoul National University Hospital, Seoul

The Catholic University Hospital, Seoul

Beatson West of Scotland Cancer Center, Glasgow

T6G 1Z2

Cross Cancer Institute- Alberta Health Services (AHS), Edmonton

V5Z 4E6

British Columbia Cancer Agency, Vancouver

M5G 2M9

Princess Margaret Cancer Centre, Toronto

06351

Samsung Medical Center, Seoul

W1G 6AD

Sarah Cannon Research Institute - HCA Healthcare, City of London

All Listed Sponsors
lead

Erasca, Inc.

INDUSTRY

NCT05907304 - A Study to Assess Naporafenib (ERAS-254) Administered With Trametinib in Patients With RAS Q61X Mutations | Biotech Hunter | Biotech Hunter