A Study of Pembrolizumab (MK-3475) in Combination With Belzutifan (MK-6482) and Lenvatinib (MK-7902), or Pembrolizumab/Quavonlimab (MK-1308A) in Combination With Lenvatinib, vs Pembrolizumab and Lenvatinib, for Treatment of Advanced Clear Cell Renal Cell Carcinoma (MK-6482-012)-China Extension Study

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

249

Participants

Timeline

Start Date

July 27, 2022

Primary Completion Date

December 1, 2026

Study Completion Date

December 1, 2026

Conditions
Carcinoma, Renal Cell
Interventions
BIOLOGICAL

Pembrolizumab

Pembrolizumab 400 mg administered Q6W via IV infusion

DRUG

Belzutifan

Belzutifan 120 mg administered QD via oral tablet

BIOLOGICAL

Pembrolizumab/Quavonlimab

Pembrolizumab/quavonlimab is a co-formulated product composed of pembrolizumab 400 mg in combination with quavonlimab 25 mg, administered Q6W via IV infusion

DRUG

Lenvatinib

Lenvatinib 20 mg administered QD via oral capsule

Trial Locations (17)

100142

Beijing Cancer hospital-Renal carcinoma and melanoma ( Site 6000), Beijing

210000

Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School-Urology ( S, Nanjing

215004

The Second Affiliated Hospital of Soochow University-Urology ( Site 6025), Suzhou

300211

The Second Hospital of Tianjin Medical University ( Site 6032), Tianjin

310003

The First Affiliated Hospital, Zhejiang University ( Site 6024), Hangzhou

314001

The First Hospital of Jiaxing ( Site 6033), Jiaxing

315010

Ningbo First Hospital-Urology ( Site 6028), Ningbo

325000

The First Affiliated Hospital of Wenzhou Medical University-Urology Surgery ( Site 6021), Wenzhou

330006

The First Affiliated Hospital of Nanchang University ( Site 6019), Nanchang

400030

Chongqing University Cancer Hospital ( Site 6009), Chongqing

430022

Wuhan Union Hospital ( Site 6002), Wuhan

450008

Henan Cancer Hospital-Urology ( Site 6006), Zhengzhou

510060

SUN YAT-SEN UNIVERSITY CANCER CENTRE ( Site 6003), Guangzhou

510120

The First Affiliated Hospital of Guangzhou Medical University-Urology ( Site 6036), Guangzhou

510180

Guangzhou First People's Hospital ( Site 6007), Guangzhou

610041

West China Hospital Sichuan University-Urology Surgery ( Site 6016), Chengdu

710061

The First Affiliated Hospital of Xi'an Jiaotong University ( Site 6014), Xi'an

All Listed Sponsors
collaborator

Eisai Inc.

INDUSTRY

lead

Merck Sharp & Dohme LLC

INDUSTRY