NCT05895747View on ClinicalTrials.gov

5-HTP and Creatine for Depression R33 Phase

PHASE2RecruitingINTERVENTIONAL
Enrollment

106

Participants

Timeline

Start Date

September 28, 2023

Primary Completion Date

June 30, 2026

Study Completion Date

July 31, 2026

Conditions
Major Depressive Disorder
Interventions
DRUG

Low Dose 5-hydroxytryptophan

5-hydroxytryptophan 100mg PO BID

DRUG

High Dose 5-hydroxytryptophan

5-hydroxytryptophan 200mg PO BID

DRUG

Low Dose Creatine Monohydrate

Creatine monohydrate 5g PO qday

DRUG

High Dose Creatine Monohydrate

Creatine monohydrate 10g PO qday

DRUG

Placebo

Creatine-matched placebo and 5-HTP-matched placebo; Placebo will be dextrose either encapsulated (5-HTP matched) or as loose powder (creatine matched)

Trial Locations (1)

84108

RECRUITING

University of Utah Department of Psychiatry, Salt Lake City

All Listed Sponsors
lead

University of Utah

OTHER