T-Dxd in Combination With Ramucirumab as HER2 Low Gastric or Gastroesophageal Junction (GEJ) Adenocarcinoma

PHASE1/PHASE2RecruitingINTERVENTIONAL
Enrollment

58

Participants

Timeline

Start Date

February 5, 2024

Primary Completion Date

December 1, 2025

Study Completion Date

January 1, 2026

Conditions
Gastric CancerGastroesophageal Junction (GEJ) Cancer
Interventions
DRUG

T-Dxd(Trastuzmab deruxtecan), Ramucirumab

"Phase Ib will use a standard 3+3 scheme with the planned doses of T-DXd (4.4\~6.4 mg/kg) once every 3 weeks in combination with Ramucirumab 8mg/kg administered once every 2 weeks.~* Dosing Regimen~ * Trastruzumab deruxtecan : One IV infusion every 3 weeks on Day 1 of each 21-day cycle~ * Ramucirumab : One IV infusion on every 2 weeks on Day 1,15 of each 28-day cycle"

Trial Locations (1)

03722

RECRUITING

Sun Young Rha, Seoul

All Listed Sponsors
lead

Yonsei University

OTHER