Study to Evaluate Suprachoroidally Administered CLS-AX in the Treatment of Neovascular Age-Related Macular Degeneration

PHASE2CompletedINTERVENTIONAL
Enrollment

60

Participants

Timeline

Start Date

May 31, 2023

Primary Completion Date

August 20, 2024

Study Completion Date

August 20, 2024

Conditions
Neovascular Age-related Macular Degeneration
Interventions
DRUG

CLS-AX

CLS-AX will be administered by suprachoroidal injection into the study eye on Day 1 and then every 12 to 24 weeks as determined by protocol-defined disease activity criteria.

DRUG

Aflibercept

Aflibercept will be administered by intravitreal injection into the study eye once every 8 weeks (Q8W).

Trial Locations (32)

21740

Cumberland Valley Retina Consultants, Hagerstown

22031

Retina Group of Washington, Fairfax

28803

Western Carolina Retinal Associates P.A., Asheville

30060

Georgia Retina, PC, Marietta

30909

Southeast Retina Center, Augusta

32503

Retina Specialty Institute, Pensacola

33308

Retina Group of Florida, Fort Lauderdale

33609

Retina Associates of Florida, Tampa

33805

Florida Retina Consultants, Lakeland

37203

Tennessee Retina PC, Nashville

50266

Wolfe Eye Clinic, Des Moines

60304

Illinois Retina Associates, Oak Park

75075

Texas Retina Associates-Plano, Plano

75231

Texas Retina Associates - Dallas, Dallas

76012

Texas Retina Associates - Arlington, Arlington

77401

Retina Consultants of Texas-Bellairre, Bellaire

77494

Retina Consultants of Texas - Katy, Katy

78240

Retina Consultants of Texas-San Antonio, San Antonio

78705

Austin Retina, Austin

79606

Retina Research Institute of Texas, Abilene

85020

Associated Retina Consultants, Phoenix

85053

Retinal Research Institute, LLC, Phoenix

89431

Sierra Eye Associates, Reno

92064

Retina Consultants San Diego, Poway

92374

Retinal Consultants of Southern California, Redlands

92835

Retina Consultants of Orange County, Fullerton

93309

California Retina Consultants, Bakersfield

94040

Northern California Retina Vitreous Associates Medical Group, Inc, Mountain View

95825

Retinal Consultants Medical Group, Inc., Sacramento

99204

Spokane Eye Clinical Research, Spokane

01605

Vitreo-Retinal Associates, PC, Worcester

07003

Envision Ocular LLC, Bloomfield

Sponsors
All Listed Sponsors
lead

Clearside Biomedical, Inc.

INDUSTRY