Efficacy and Safety of Fluzoparib Combined With Adjuvant Endocrine Therapy for HR+/HER2- SNF3-subtype Early Breast Cancer (BCTOP-L-A01)

PHASE3RecruitingINTERVENTIONAL
Enrollment

766

Participants

Timeline

Start Date

June 1, 2023

Primary Completion Date

May 31, 2028

Study Completion Date

May 31, 2031

Conditions
Breast Cancer
Interventions
DRUG

Fluzoparib

Fluzoparib 50mg bid orally for 1 year.

DRUG

Anastrozole

1mg, qd orally

DRUG

Letrozole

2.5mg, qd orally

DRUG

Exemestane

25mg, qd orally

DRUG

Tamoxifen

10mg, bid orally

DRUG

Toremifene

60mg, qd orally

DRUG

Abemaciclib

150mg/100mg/50mg, bid orally for 2 years

DRUG

LHRH agonist

Leuprorelin acetate, goserelin acetate

Trial Locations (15)

100142

RECRUITING

Beijing Cancer Hospital, Beijing

110002

RECRUITING

The First Hospital of China Medical University, Shenyang

110801

RECRUITING

Liaoning Cancer Hospital & Institute, Shenyang

200032

RECRUITING

Fudan University Shanghai Cancer Center, Shanghai

200233

RECRUITING

Shanghai Sixth People's Hospital Affiliated to Shanghai Jiaotong University, Shanghai

201204

RECRUITING

Shanghai First Maternity and Infant Hospital, Shanghai

225009

RECRUITING

Northern Jiangsu People's Hospital, Yangzhou

226006

RECRUITING

Affiliated Hospital of Nantong University, Nantong

350001

RECRUITING

Fujian Medical University Union Hospital, Fuzhou

400030

RECRUITING

Chongqing Cancer Hospital, Chongqing

510062

RECRUITING

Sun Yat-sen University Cancer Center, Guangdong

519041

RECRUITING

Guangdong Academy of Medical Sciences Guangdong Provincial People's Hospital, Guangzhou

610041

RECRUITING

West China Hospital of Sichuan University, Chengdu

710061

RECRUITING

The First Affiliated Hospital of Xi'an Jiaotong University, Xi’an

Unknown

RECRUITING

Ningbo Medical Center Lihuili Hospital, Ningbo

All Listed Sponsors
lead

Fudan University

OTHER