Intra-Tumoral Injections of Natural Killer Cells for Recurrent Malignant Pediatric Brain Tumors

PHASE1RecruitingINTERVENTIONAL
Enrollment

24

Participants

Timeline

Start Date

May 31, 2024

Primary Completion Date

December 31, 2027

Study Completion Date

December 31, 2027

Conditions
Pediatric Brain TumorRecurrent Pediatric Brain TumorPediatric Neoplasm
Interventions
BIOLOGICAL

Universal Donor (UD) Transforming growth factor beta imprinting (TGFβi) Natural Killer (NK) Cells

The TGFβi NK cell product will be manufactured in the Cell Therapy Laboratory at Nationwide Children's Hospital and given via infusion.

PROCEDURE

Implantation

Undergo placement of Ommaya reservoir

PROCEDURE

Magnetic Resonance Imaging (MRI)

Imaging procedure

OTHER

Quality-of-Life Assessment

Ancillary studies

Trial Locations (6)

21287

RECRUITING

Johns Hopkins, Baltimore

35294

RECRUITING

University of Alabama Birmingham, Birmingham

46202

RECRUITING

Indiana University, Indianapolis

63130

RECRUITING

Washington University in Saint Louis, St Louis

94143

RECRUITING

University of California, San Francisco, San Francisco

07601

RECRUITING

Hackensack University Medical Center, Hackensack

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Rally Foundation

UNKNOWN

collaborator

Washington University School of Medicine

OTHER

collaborator

Nationwide Children's Hospital

OTHER

collaborator

CureSearch

UNKNOWN

collaborator

Tommy Strong Foundation

UNKNOWN

lead

Sabine Mueller, MD, PhD

OTHER