A Study of an Intermittent ADT Approach With Apalutamide Monotherapy in Participants With mCSPC

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

420

Participants

Timeline

Start Date

August 31, 2023

Primary Completion Date

August 31, 2026

Study Completion Date

August 31, 2026

Conditions
Metastatic Castrate-sensitive Prostate Cancer
Interventions
DRUG

Apalutamide

Apalutamide will be administered orally from Day 1 of Cycle 1 till 6 months in initial treatment phase and then in main treatment phase from Day 1 of Cycle 7 up to at least 18 months.

DRUG

Androgen-deprivation Therapy (ADT)

The choice of ADT will be at discretion of the Investigator. Dosing (dose and frequency of administration) will be consistent with the prescribing information.

Trial Locations (92)

2109

Macquarie University Hospital, Macquarie University

3000

Peter MacCallum Cancer Centre, Melbourne

4101

Mater Misericordiae Hospital, South Brisbane

10032

Columbia University Medical Center, New York

10065

Memorial Sloan Kettering Cancer Center, New York

10604

MSKCC Westchester, Harrison

11553

MSKCC Nassau Regional Cancer Center, Uniondale

11725

MSKCC Commack, Commack

13210

Associated Medical Professionals, Syracuse

15232

University of Pittsburgh Medical Center, Pittsburgh

15240

VA Pittsburgh, Pittsburgh

19004

Centers for Advanced Urology LLC d b a MidLantic Urology, Bala-Cynwyd

20904

Maryland Oncology Hematology P A, Silver Spring

21204

Chesapeake Urology Research Associates, Towson

23462

Urology Of Virginia, Pllc, Virginia Beach

23502

Virginia Oncology Associates, Norfolk

23538

Universitatsklinikum Schleswig Holstein Campus Lubeck, Lübeck

31207

SCIENTIA Investigacion Clinica SC, Chihuahua City

32114

Advanced Urology Institute, Daytona Beach

33076

Institut Bergonie, Bordeaux

34000

Consultorio de Especialidad en Urologia Privado, Durango

35000

Chu Rennes Hopital Pontchaillou, Rennes

35209

Urology Centers Of Alabama, Homewood

37209

Urology Associates, Nashville

38138

The Conrad Pearson Clinic, Germantown

43230

Central Ohio Urology Group, Gahanna

44130

Helios Clinical Research, LLC, Middleburg Heights

45212

TriState Urologic Services PSC Inc. DBA The Urology Group, Cincinnati

46143

Urology of Indiana, Greenwood

47130

First Urology, PSC, Jeffersonville

48084

Michigan Institute of Urology, Troy

50937

Universitaetsklinikum Koelnt, Cologne

52074

Universitaetsklinikum der RWTH Aachen, Aachen

60415

Associated Urological Specialists LLC, Chicago Ridge

60431

Advanced Urology Associates, Joliet

69373

Centre Leon Berard, Lyon

72211

Arkansas Urology, Little Rock

72622

Studienpraxis Urologie Nurtingen, Nürtingen

75014

Hopital Cochin, Paris

75235

Parkland Health and Hospital System, Dallas

75246

Texas Oncology P A, Dallas

75390

UT Southwestern Medical Center, Dallas

76000

Cuidados Oncologicos, Querétaro

76310

Texas Oncology P A, Wichita Falls

77024

Texas Oncology P A, Houston

77027

Houston Metro Urology, Houston

78217

Texas Oncology San Antonio Northeast, San Antonio

78731

Texas Oncology P A, Austin

80228

Colorado Clinical Research, Lakewood

81675

Klinikum rechts der Isar - der Technischen Universität München, München

84112

University of Utah Huntsman Cancer Institute, Salt Lake City

85741

Arizona Urology Specialists, Tucson

93105

Sansum Clinic Pharm, Santa Barbara

93720

Urology Associates of Central California, Fresno

94121

VA Medical Center, San Francisco

94805

Gustave Roussy, Villejuif

97070

Medical Care & Research SA de CV, Mérida

97080

Universitatsklinikum Wurzburg, Würzburg

97223

Northwest Cancer Specialists PC, Tigard

98684

Oncology and Hematology Associates of Southwest Virginia, Inc., Roanoke

100034

Peking University First Hospital, Beijing

110004

Shengjing Hospital Of China Medical University, Shenyang

130021

The First Hospital of Jilin University, Changchun

250021

Shandong Provincial Hospital, Jinan

315010

Ningbo First Hospital, Ningbo

430030

TongJi Hospital of TongJi Medical College of Huazhong University of Science & Technology, Wuhan

510080

The First Affiliated Hospital Sun Yat sen University, Guangzhou

510515

Nanfang Hospital of Southern Medical Hospital, Guangzhou

610041

West China School of Medicine/West China Hospital, Sichuan University, Chengdu

710061

The First Affiliated Hospital of Xian Jiaotong University, Xi'an

07920

MSKCC Basking Ridge, Basking Ridge

07748

MSKCC Monmouth, Middletown

07645

MSKCC Bergen, Montvale

14784 400

Fundacao Pio XII, Barretos

30130-100

Hospital das Clínicas - Universidade Federal de Minas Gerais, Belo Horizonte

59062 000

Liga Norte Riograndense Contra O Cancer, Natal

20230-130

Ministerio da Saude Instituto Nacional do Cancer, Rio de Janeiro

41253 190

Instituto D Or de Pesquisa e Ensino, Salvador

09060-650

CEPHO Centro de Estudos e Pesquisa de Hematologia e Oncologia, Santo André

01246 000

Fundacao Faculdade de Medicina Instituto do Cancer do Estado de Sao Paulo, São Paulo

T2V 1P9

Southern Alberta Institute of Urology / Prostate Cancer Centre, Calgary

B3H 2Y9

Nova Scotia Health Authority, Halifax

M4N 3M5

Sunnybrook Health Sciences Center, Toronto

M5G 2M9

Princess Margaret Hospital, Toronto

G1J 1Z4

CHU de Quebec Universite Laval Hopital de l Enfant Jesus, Québec

D-86158

Klinikum Augsburg, Augsburg

01307

Universitaetsklinikum Carl Gustav Carus TU Dresden, Dresden

85 796

Centrum Onkologii im Prof F Lukaszczyka, Bydgoszcz

75-581

Szpital Wojewodzki im Mikolaja Kopernika w Koszalinie, Koszalin

02 781

Narodowy Instytut Onkologii im Marii Sklodowskiej Curie Panstwowy Instytut Badawczy, Warsaw

04 073

Szpital Grochowski Im Dr Med Rafala Masztaka Sp Z O O, Warsaw

53 329

Polimed Specjalistyczna Przychodnia Lekarska Wieslaw Grazyna Tupikowski Bednarek Tupikowska S C, Wroclaw

All Listed Sponsors
lead

Janssen Research & Development, LLC

INDUSTRY

NCT05884398 - A Study of an Intermittent ADT Approach With Apalutamide Monotherapy in Participants With mCSPC | Biotech Hunter | Biotech Hunter