Phase 2 Study of AFM13 in Combination With AB-101 in Subjects With R/R HL and CD30+ PTCL

PHASE2TerminatedINTERVENTIONAL
Enrollment

25

Participants

Timeline

Start Date

October 10, 2023

Primary Completion Date

November 7, 2024

Study Completion Date

June 13, 2025

Conditions
Relapsed or Refractory Hodgkin LymphomaPeripheral T Cell Lymphoma
Interventions
DRUG

AFM13

anti-human CD30 × anti-human CD16A recombinant antibody therapy, intravenous infusion

DRUG

AB-101

NK cell therapy, intravenous infusion

DRUG

Cyclophosphamide

Lymphodepleting chemotherapy, intravenous infusion

DRUG

Fludarabine

Lymphodepleting chemotherapy, intravenous infusion

DRUG

Interleukin-2

Immune cytokine, subcutaneously

Trial Locations (15)

10065

Memorial Sloan Kettering Cancer Center, New York

19104

University of Pennsylvania, Abramson Cancer Center, Philadelphia

19111

Fox Chase Cancer Center, Philadelphia

27599

UNC Immunotherapy Team, University of North Carolina at Chapel Hill, Chapel Hill

35294

O'Neal Comprehensive Cancer Center at UAB, Birmingham

40207

Norton Cancer Institute, Louisville

44195

Cleveland Clinic, Cleveland

48201

Karmanos Cancer Institute, Detroit

55455

Masonic Cancer Center, University of Minnesota, Minneapolis

63110

Washington University School of Medicine, St Louis

80218

Sarah Cannon Research Institute, Denver

91010

City of Hope National Medical Center, Duarte

92868

UC Irvine Health, Orange

02215

Beth Israel Deaconess Medical, Boston

07601

John Theurer Cancer Center, Hackensack

Sponsors

Lead Sponsor

All Listed Sponsors
collaborator

Artiva Biotherapeutics, Inc.

INDUSTRY

lead

Affimed GmbH

INDUSTRY

NCT05883449 - Phase 2 Study of AFM13 in Combination With AB-101 in Subjects With R/R HL and CD30+ PTCL | Biotech Hunter | Biotech Hunter