EPI-MINN: Targeting Cognition and Motivation - National

NAActive, not recruitingINTERVENTIONAL
Enrollment

200

Participants

Timeline

Start Date

May 30, 2023

Primary Completion Date

June 30, 2026

Study Completion Date

June 30, 2026

Conditions
PsychosisPsychosis Nos/OtherSchizophreniaSchizo Affective DisorderSchizoaffective DisorderProdromal SchizophreniaSchizophrenia Spectrum and Other Psychotic DisordersSchizophreniform DisordersMajor Depression With Psychotic FeaturesUnspecified PsychosisBipolar Disorder
Interventions
DEVICE

Cognitive and Social Cognitive Training

"The Cognitive Training Module is designed to improve the speed and accuracy of auditory information processing while engaging working memory and cognitive control under conditions of close attention and reward. The goal is to increase the effectiveness by which salient stimuli engage and drive plastic changes in brain systems that in individuals with psychosis exhibit relatively poor temporal response.~The Social Cognition Training Module consists of exercises designed to ameliorate core deficits in social cognition expressed in schizophrenia and Autism Spectrum Disorders. The exercises apply principles of implicit learning to restore the brain's capacity to process and utilize socially-relevant information, and include training to improve affect perception, social cue perception, theory of mind, self-referential style, and emotion labeling and working memory."

BEHAVIORAL

Personalized Real-Time Intervention for Motivational Enhancement (PRIME) App

The PRIME smartphone-based app is designed to be used for 12 weeks to enhance motivation in people with early psychosis. Participants work towards self-identified goals with the support of the virtual community of age-matched peers, as well as with motivation coaches. Participants discuss their interests and aspirations with each other and with their coach, and the coach sends daily individualized motivational messages. Coaches also provide tailored interventions to enhance motivation, and post daily discussion topics to the PRIME community to encourage interaction between members. Coaches will maintain close communication and feedback on progress with each individual's clinical team.

OTHER

Early Psychosis Coordinated Specialty Care

Participants will continue to engage in treatment as usual at their early psychosis coordinated specialty care clinic. These clinics may follow the NAVIGATE model, as an example.

Trial Locations (1)

55454

University of Minnesota Department of Psychiatry & Behavioral Sciences, Minneapolis

All Listed Sponsors
collaborator

National Institute of Mental Health (NIMH)

NIH

lead

University of Minnesota

OTHER