360
Participants
Start Date
June 23, 2023
Primary Completion Date
December 29, 2025
Study Completion Date
December 29, 2025
Efinopegdutide
Subcutaneous (SC) injection in dose-escalation regimens potentially including doses of 2 mg, 4 mg, 7 mg, and 10 mg
Semaglutide
SC injection in a dose-escalation regimen of 0.25 mg, 0.5 mg, 1.0 mg, 1.7 mg, and 2.4 mg
Placebo
SC injection of matching placebo
Taichung Veterans General Hospital ( Site 2703), Taichung
Chiayi Christian Hospital ( Site 2707), Chiayi City
National Cheng Kung University Hospital-Liver Research team of National Cheng Kung University Hospi, Tainan City
SYNEXUS Magyarország Kft. Eü. ( Site 1110), Budapest
Dél-Pesti Centrumkórház-Hepatologiai Szakrendekő ( Site 1102), Budapest
Antwerp University Hospital-Gastr-enterologie/hepatologie ( Site 3300), Edegem
UZ Leuven-Hepatology ( Site 3302), Leuven
Fondazione Epatocentro Ticino ( Site 2602), Lugano
Medizinische Universität Graz-Department of Internal Medicine ( Site 0302), Graz
UniversitätsSpital Zürich-Gastroenterologie & Hepatologie ( Site 2603), Zurich
AZ Maria Middelares-Digestief Centrum ( Site 3301), Ghent
Cantonal Hospital St.Gallen-Klinik für Gastroenterologie / Hepatologie ( Site 2601), Sankt Gallen
National Taiwan University Hospital-Internal Medicine ( Site 2700), Taipei
New York Gastroenterology Associates ( Site 3252), New York
Azienda Ospedaliero-Universitaria Città della Salute e della-S.C. Gastroenterologia U. ( Site 1401), Torino
Chulalongkorn University ( Site 2800), Bangkok
Faculty of Medicine Siriraj Hospital-Department of Medicine ( Site 2802), Bangkok
Taipei Veterans General Hospital-Division of Gastroenterology & Hepatology, Department of Medicine (, Taipei
Centro de investigacion Clínica Trujillo ( Site 1802), Trujillo
Velocity Clinical Research, Syracuse ( Site 3227), East Syracuse
Hospital General de Tomelloso-Aparato Digestivo ( Site 2514), Tomelloso
Medica Sur-Clinica de Enfermedades Digestivas y Obesidad ( Site 1603), Mexico City
CHUAC-Complejo Hospitalario Universitario A Coruña-Endocrinología ( Site 2511), A Coruña
CLINICA DELGADO-Clinical Research ( Site 1800), Miraflores
CHUS - Hospital Clinico Universitario ( Site 2503), Santiago de Compostela
Instituto Médico Soy Diabetico ( Site 1804), Piura
Humanitas-Medicina interna ed Epatologia ( Site 1400), Rozzano
Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico ( Site 1403), Milan
Inha University Hospital-Gastroenterolgy/Hepatology ( Site 2402), Incheon
Gastroenterology Consultants of Southwest Virginia ( Site 3282), Roanoke
Hospital Universitario Ramón y Cajal ( Site 2508), Madrid
Hospital Universitario La Paz-HEPATOLOGIA ( Site 2509), Madrid
HOSPITAL UNIVERSITARIO PUERTA DE HIERRO MAJADAHONDA-Gastroenterologia y Hepatologia ( Site 2500), Madrid
Hospital Universitario Virgen de la Victoria-UGC Endocrinologia y nutricion ( Site 2506), Málaga
Southeast Clinical Research Center ( Site 3288), Dalton
ICARO Investigaciones en Medicina ( Site 1608), Chihuahua City
Velocity Clinical Research, Hallandale Beach ( Site 3241), Hallandale
Indago Research & Health Center, Inc ( Site 3207), Hialeah
Sweet Hope Research Specialty, Inc-Research ( Site 3200), Hialeah
Genoma Research Group ( Site 3242), Miami
Top Medical Research ( Site 3209), Cutler Bay
Chang Gung Medical Foundation-Linkou Branch ( Site 2702), Taoyuan District
Excel Medical Clinical Trials ( Site 3246), Boca Raton
Synergy Healthcare LLC ( Site 3290), Brandon
CHU Bordeaux Haut-Leveque-Service d'Hépato-gastroentérologie ( Site 0904), Pessac
Covenant Metabolic Specialists, LLC ( Site 3231), Fort Myers
Bezmialem Vakf Üniversitesi-Gastroenterology ( Site 2903), Istanbul
Synergy Healthcare ( Site 3286), Bradenton
Florida Research Institute ( Site 3243), Lakewood Rch
T.C. Sağlik Bakanliği- Marmara Üniversitesi İstanbul Pendik -T.C. Sağlik Bakanliği- Marmara Ünivers, Istanbul
Dokuz Eylul Universitesi Hastanesi-Gastroenterology ( Site 2905), Izmir
Hospital Universitario Marqués de Valdecilla-Gastroenterology and Hepatology ( Site 2505), Santander
HOSPITAL UNIVERSITARIO VIRGEN DEL ROCIO-Unidad de Ensayos Clínicos de Aparato Digestivo ( Site 2504), Seville
Velocity Clinical Research, Cincinnati ( Site 3237), Cincinnati
Centre Hospitalier Universitaire d'Angers-Hepato Gastroenterology ( Site 0900), Angers
Changhua Christian Hospital-Endocrinology and metabolism ( Site 2704), Changhua County
Maharaj Nakorn Chiang Mai Hospital ( Site 2801), Muang
University of Iowa ( Site 3213), Iowa City
Recep Tayyip Erdogan University Training and Research Hospital ( Site 2900), Rize
Eagle Clinical Research ( Site 3233), Chicago
Centre Hospitalier Universitaire Estaing ( Site 0913), Clermont-Ferrand
Kansas City Research Institute ( Site 3249), Kansas City
"Hospital Universitario Dr. Jose Eleuterio Gonzalez ( Site 1604)", Monterrey
Servicios de Oncología Médica Integral - Monterrey ( Site 1611), Monterrey
Oaxaca Site Management Organization ( Site 1613), Oaxaca City
Centro de Investigacion Clinica de Oaxaca ( Site 1607), Oaxaca City
Hôpital de la Croix Rousse-Centre de Recherche Clinique ( Site 0911), Lyon
Velocity Clinical Research, Dallas ( Site 3220), Dallas
Hôpital Saint Antoine ( Site 0914), Paris
Hopitaux Universitaires Paris Centre-Hopital Cochin-Service HEPATOLOGIE- Recherche Clinique ( Site 0, Paris
CHU Charles Nicolle ( Site 0910), Rouen
Houston Research Institute ( Site 3262), Houston
American Research Corporation ( Site 3202), San Antonio
Pinnacle Clinical Research ( Site 3284), San Antonio
South Texas Research Institute - Brownsville ( Site 3285), Brownsville
Velocity Clinical Research, Austin ( Site 3235), Austin
Velocity Clinical Research, Salt Lake City ( Site 3223), West Jordan
The Institute for Liver Health II dba Arizona Clinical Trial-The Institute for Liver Health ( Site 3, Chandler
The Institute for Liver Health II dba Arizona Clinical Trials - Peoria ( Site 3289), Peoria
The Institute for Liver Health II dba Arizona Liver Health-Tucson ( Site 3218), Tucson
Del Sol Research Management, LLC ( Site 3211), Tucson
The Machuca Foundation ( Site 3234), Las Vegas
Velocity Clinical Research, Westlake ( Site 3216), Los Angeles
A.O.U. Policlinico Paolo Giaccone-Dep. Of Internal Medicine and Specialistic ( Site 1402), Palermo
Velocity Clinical Research, Gardena ( Site 3225), Gardena
Velocity Clinical Research, Huntington Park ( Site 3217), Huntington Park
California Liver Research Institute ( Site 3232), Pasadena
Velocity Clinical Research, Panorama City ( Site 3214), Panorama City
Velocity Clinical Research, San Diego ( Site 3226), La Mesa
Hôpital Beaujon-Hépatologie ( Site 0908), Clichy
Om Research - Apple Valley ( Site 3244), Apple Valley
Om Research LLC ( Site 3245), Camarillo
Om Research LLC ( Site 3229), Lancaster
Clinical Trials Research ( Site 3230), Sacramento
Beijing Youan Hospital ( Site 0602), Beijing
Beijing Tsinghua Changgung Hospital ( Site 0606), Beijing
Fundacion Santa Fe de Bogota ( Site 0701), Bogotá
Solano & Terront Servicios Medicos - UNIENDO ( Site 0705), Bogotá
Singapore General Hospital ( Site 2188), Singapore
Sociedad De Oncología y Hematología Del Cesar SAS ( Site 0708), Valledupar
No. 2 Hospital of Nanjing ( Site 0605), Nanjing
Oncomédica S.A.S ( Site 0702), Montería
Tianjin Second People's Hospital ( Site 0604), Tianjin
The First Affiliated Hospital of Wenzhou Medical University ( Site 0609), Wenzhou
Chongqing University Three Gorges Hospital ( Site 0607), Wanzhou
The First Affiliated Hospital, Sun Yat-sen University ( Site 0603), Guangzhou
Southern Medical University Nanfang Hospital ( Site 0601), Guangzhou
West China Hospital, Sichuan University ( Site 0611), Chengdu
Fundación Valle del Lili ( Site 0700), Santiago de Cali
Rambam Health Care Campus ( Site 1304), Haifa
Carmel Hospital ( Site 1305), Haifa
Maccabi Health Services - Ramat Hasharon ( Site 1303), Ramat HaSharon
Sheba Medical Center ( Site 1300), Ramat Gan
Enroll SpA ( Site 0501), Providencia
Barzilai Medical Center ( Site 1306), Ashkelon
Ehime University Hospital ( Site 1509), Tōon
CECIM ( Site 0500), Santiago
Pontificia Universidad Catolica de Chile-CICUC ( Site 0502), Santiago
Shaare Zedek Medical Center-Liver Unit ( Site 1302), Jerusalem
Floridian Clinical Research, LLC ( Site 3203), Miami Lakes
Velocity Clinical Research, Providence ( Site 3222), East Greenwich
Heritage Medical Research Clinic ( Site 0403), Calgary
Vancouver General Hospital-Gastroenterology ( Site 0408), Vancouver
Toronto General Hospital ( Site 0402), Toronto
McGill University Health Centre ( Site 0400), Montreal
Diex Recherche Quebec Inc. ( Site 0409), Québec
Fundación Centro de Investigación Clínica CIC ( Site 0704), Medellín
KlinMed ( Site 0801), Prague
Krajská nemocnice Liberec ( Site 0800), Liberec
Vseobecna fakultni nemocnice v Praze ( Site 0802), Prague
Centre Hospitalier Universitaire de Nice - Hôpital l'Archet-Pôle de Référence Hépato Gastro-entérol, Nice
centre hospitalier lyon sud-Endocrinologie, Diabète et Nutrition ( Site 0906), Pierre-Bénite
Prince of Wales Hospital ( Site 1000), Shatin
Rabin Medical Center ( Site 1301), Petah Tikva
Fondazione Policlinico Universitario Agostino Gemelli IRCCS -Dipartimento di Medicina Interna e Gas, Rome
Kurume University Hospital ( Site 1504), Kurume
Ogaki Municipal Hospital ( Site 1511), Ōgaki
Sapporo Kosei General Hospital ( Site 1521), Sapporo
Kagawa University Hospital ( Site 1515), Kita
Kagawa Prefectural Central Hospital ( Site 1514), Takamatsu
Toranomon Hospital Kajigaya ( Site 1502), Kawasaki
Toranomon Hospital ( Site 1501), Minato-ku
Shinyurigaoka General Hospital ( Site 1518), Kawasaki
St. Marianna University Hospital ( Site 1516), Kawasaki
Yokohama City University Hospital ( Site 1505), Yokohama
Shinshu University Hospital ( Site 1512), Matsumoto
Nara Medical University Hospital ( Site 1513), Kashihara
Osaka Saiseikai Suita Hospital ( Site 1503), Suita
Fukuiken Saiseikai Hospital ( Site 1507), Fukui
Gifu Municipal Hospital ( Site 1506), Gifu
University Hospital,Kyoto Prefectural University of Medicine ( Site 1519), Kyoto
Kawasaki Medical School General Medical Center ( Site 1508), Okayama
Osaka Metropolitan University Hospital ( Site 1520), Osaka
Saga University Hospital ( Site 1510), Saga
Japanese Red Cross Musashino Hospital ( Site 1517), Tokyo
Centro de Investigación y Gastroenterología ( Site 1601), Cuauhtémoc
Centro de Investigación y Gastroenterología - S.C. ( Site 1609), Mexico City
Unidade Local de Saúde do Alto Ave - Hospital Senhora da Oliveira ( Site 1905), Guimarães
Unidade Local de Saude Lisboa Ocidental - Hospital Egas Moniz ( Site 1906), Lisbon
Unidade Local de Saude de Santa Maria - Hospital de Santa Maria ( Site 1904), Lisbon
ULSAM - Hospital de Santa Luzia ( Site 1907), Viana do Castelo
ISIS CLINICAL RESEARCH CENTER ( Site 2006), Guaynabo
Pan American Center for Oncology Trials ( Site 2000), Rio Piedras
Klinical Investigations Group-Clinical Research ( Site 2001), San Juan
Latin Clinical Trial Center ( Site 2004), San Juan
Boramae Medical Center-Internal Medicine ( Site 2403), Dongjak-gu
Severance Hospital, Yonsei University Health System ( Site 2401), Seoul
Samsung Medical Center-Gastroenterology/Internal Medicine ( Site 2400), Seoul
Hospital Universitari Vall d'Hebron-Liver Unit - Department of Internal Medicine ( Site 2507), Barcelona
Hacettepe Universite Hastaneleri-internal diseases ( Site 2901), Ankara
Royal London Hospital ( Site 3003), London
King's College Hospital ( Site 3002), London
Aberdeen Royal Infirmary-Department of Gastroenterology ( Site 3004), Aberdeen
Queen Elizabeth Hospital Birmingham ( Site 3000), Birmingham
St James's University Hospital ( Site 3005), Leeds
Merck Sharp & Dohme LLC
INDUSTRY