Short Course Primaquine for the Radical Cure of P. Vivax - Papua New Guinea

"1. Point-of-care quantitative G6PD testing using G6PD STANDARD (SD Biosensor) prior to use of primaquine (Day 0)~2. Prescription of short course primaquine (7 mg/kg total) (Day 0):~ * PQ7 (1 mg/kg/day for 7 days) if G6PD activity greater than 70 percent~ * PQ14 (0.5 mg/kg/day for 14 days) if G6PD activity is 30-70 percent~ * PQ8w (0.75 mg/kg/week for 8 weeks) if G6DP activity less than 30 percent~3. Participant counselling at the health facility (Day 0):~ * Supervision of first dose of primaquine~ * Education regarding importance and risks of primaquine therapy and necessity to take primaquine with food~4. Community based clinical review on Day 3 (and Day 7 for the first 300 participants) to detect and manage gastrointestinal or haemolytic adverse effects of treatment and encourage adherence to full treatment regime~5. Improved malariometric surveillance and pharmacovigilance to support wider scale use of the revised case management"