NCT05867121 - A Study to Evaluate Safety, Pharmacokinetics, & Activity of RO7496353 in Combination With a Checkpoint Inhibitor With or Without Standard-of-care Chemotherapy in Participants With Locally Advanced or Metastatic Solid Tumors; Urothelial Carcinoma Substudy in Association With RO7496353 Study GO44010 | Biotech Hunter

Enrollment

102

Participants

Timeline

Start Date

October 2, 2023

Primary Completion Date

June 30, 2026

Study Completion Date

June 30, 2026

Conditions

Non-small Cell Lung CancerGastric CancerPancreatic Ductal Adenocarcinoma

Interventions

DRUG

RO7496353

RO7496353 will be administered as per the schedules specified in the respective arms.

DRUG

Atezolizumab

Atezolizumab will be administered as per the schedules specified in the respective arms.

DRUG

Capecitabine

Capecitabine will be administered as per the schedule specified in the respective arm.

DRUG

S-1

S-1 will be administered as per the schedule specified in the respective arm.

DRUG

Nivolumab

Nivolumab will be administered as per the schedule specified in the respective arm.

DRUG

Oxaliplatin

Oxaliplatin will be administered as per the schedule specified in the respective arm.

DRUG

Nab-paclitaxel

Nab-paclitaxel will be administered as per the schedule specified in the respective arm.

DRUG

Gemcitabine

Gemcitabine will be administered as per the schedule specified in the respective arm.

Trial Locations (29)

1023

Auckland City Hospital, Auckland

2010

St Vincent'S Hospital, Darlinghurst

5042

Flinders Medical Centre, Bedford Park

11070

Clinical Hospital Center Bezanijska Kosa, Belgrade

19107

Thomas Jefferson University, Philadelphia

20162

ASST Grande Ospedale Metropolitano Niguarda - Presidio Ospedaliero Ospedale Niguarda Ca' Granda, Milan

28027

Clinica Universidad de Navarra-Madrid, Madrid

28223

NEXT Oncology-Hospital Quironsalud Madrid, Pozuelo de Alarcón

31008

Clinica Universitaria de Navarra, Pamplona

35340

Dokuz Eylul Universitesi Tip Fakultesi, Lzmir

37134

Centro Ricerche Cliniche Di Verona, Verona

46010

Hospital Clinico Universitario de Valencia, Valencia

90095

UCLA University of California Los Angeles, Los Angeles

06510-3206

Yale School of Medicine, New Haven

90560-030

Hospital de Clinicas de Porto Alegre (HCPA) - PPDS, Porto Alegre

90610-000

Hospital Sao Lucas Da Pontificia Universidade Catolica Do Rio Grande Do Sul (PUCRS), Porto Alegre

14784-400

Hospital de Câncer de Barretos, Barretos

00168

Fondazione Policlinico Universitario A Gemelli, Rome

277-8577

National Cancer Center Hospital East, Chiba

241-8515

Kanagawa Cancer Center, Kanagawa

411-8777

Shizuoka Cancer Center, Shizuoka

104-0045

National Cancer Center Hospital, Tokyo

135-8550

The Cancer Institute Hospital of Japanese Foundation For Cancer Research, Tokyo

03080

Seoul National University Hospital, Seoul

05505

Asan Medical Center, Seoul

06351

Samsung Medical Center - PPDS, Seoul

06591

The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul

120-752

Severance Hospital Yonsei University Health System - Clinical Trials Center Pharmacy, Seoul

06800

Ankara City Hospital, Ankara