108
Participants
Start Date
January 27, 2025
Primary Completion Date
November 30, 2027
Study Completion Date
January 31, 2028
Psilocybin
The psilocybin is produced under Good Manufacturing Practice and is in a capsule that contains 25 mg of botanically-derived psilocybin.
Transcutaneous auricular Vagus Nerve Stimulation (taVNS)
For both the active and sham taVNS procedure, participants will be provided with, and trained on, taVNS devices that apply gentle stimulation to the left ear via either electrodes or an earpiece that fits over the left ear.
Psychosocial Support Alone
Participants assigned to Psychosocial Support Alone will not receive taVNS following psilocybin dosing.
Sham taVNS
For both the active and sham taVNS procedure, participants will be provided with, and trained on, taVNS devices that apply gentle stimulation to the left ear via either electrodes or an earpiece that fits over the left ear.
RECRUITING
University of Wisconsin - Madison, Madison
Tiny Blue Dot Foundation
OTHER
University of Wisconsin, Madison
OTHER