150
Participants
Start Date
June 2, 2023
Primary Completion Date
May 13, 2025
Study Completion Date
January 31, 2026
MIL62
An intravenous (IV) infusion of 1000 mg of MIL62 will be administered at Week 1 and Week 3.If the treatment is effective, MIL62 will continue be administered at W25 and W27
Cyclosporine
Participants will receive Cyclosporine at a starting oral dose 3.5 mg/kg/d in 2 divided doses, try to give every 12 hours.The dose was adjusted according to the blood concentration of cyclosporine monitored every 2 weeks±3 days until the target blood concentration of 125\~175 ng/mL was reached.Optimized cyclosporine dose will be maintained for a maximum 52 weeks dependent on response and then tapered over 8 weeks.
Peking University First Hospital, Beijing
Beijing Mabworks Biotech Co., Ltd.
INDUSTRY