Neoadjuvant Treatment of Tislelizumab Combined Chemotherapy for Locally Advanced Oral Squamous Cell Carcinoma :A Single-arm, Prospective, Phase II Trial

PHASE2RecruitingINTERVENTIONAL
Enrollment

30

Participants

Timeline

Start Date

May 8, 2023

Primary Completion Date

June 30, 2024

Study Completion Date

June 30, 2028

Conditions
Oral Squamous Cell Carcinoma
Interventions
DRUG

Tislelizumab

The participants will receive 3 cycles of Tislelizumab, with 21 days each. 200mg of Tislelizumab will be used intravenously on the first day of each cycle.

DRUG

Albumin paclitaxel

The participants will receive 3 cycles of Albumin paclitaxel, with 21 days each. 200mg/m\^2 of Albumin paclitaxel will be used intravenously on the first day of each cycle.

DRUG

Cisplatin

The participants will receive 3 cycles of Cisplatin, with 21 days each. 20mg/m\^2 of Cisplatin will be used intravenously on days 1 through 3 of each cycle.

DRUG

5-Fluorouracil

The participants will receive 3 cycles of 5-Fluorouracil, with 21 days each. 600mg/m\^2/d of 5-Fluorouracil will be used as a 120-hour continuous intravenous infusion on days 1 through 5.

Trial Locations (1)

Unknown

RECRUITING

First affiliated hospital, School of Medicine, Zhejiang University, Hangzhou

All Listed Sponsors
lead

Weijia Fang, MD

OTHER