A Study of AK104 With Chemotherapy as First-line Treatment in Patients With Advanced Pancreatic Cancer

PHASE2RecruitingINTERVENTIONAL
Enrollment

78

Participants

Timeline

Start Date

May 25, 2023

Primary Completion Date

June 30, 2025

Study Completion Date

December 31, 2025

Conditions
Pancreatic Cancer
Interventions
DRUG

AK104

AK104 (6mg/kg) on day 1, IV, Q2W

DRUG

AK104

AK104 (10mg/kg) on day 1, IV, Q2W

DRUG

Gemcitabine

Gemcitabine (1000mg/m2) on days 1, 8 and 15, IV, Q4W

DRUG

Nab-Paclitaxel

Nab-Paclitaxel (125mg/m2) on days 1, 8 and 15, IV, Q4W

DRUG

Liposomal Irinotecan, Oxaliplatin, 5-Fluorouracil/Calcium folinate

liposomal irinotecan 50 mg/m², oxaliplatin 60 mg/m², leucovorin 400 mg/m², and fluorouracil 2400 mg/m², administered sequentially as a continuous intravenous infusion over 46 h

DRUG

Oxaliplatin + Irinotecan + 5-Fluorouracil/Leucovorin

oxaliplatin, 85 mg/m²; irinotecan, 180 mg/m²; leucovorin, 400 mg/m²; and fluorouracil, 400 mg/m² given as a bolus followed by 2400 mg per square meter given as a 46-hour continuous infusion, every 2 weeks

Trial Locations (7)

100005

RECRUITING

Peking Union Medical College Hospital, Beijing

200433

RECRUITING

Shanghai Changhai Hospital, Shanghai

250117

RECRUITING

Shandong Cancer Hospital, Jinan

310005

RECRUITING

Zhejiang Cancer Hospital, Hangzhou

510000

RECRUITING

Sun Yat-sen University Cancer Center, Guangzhou

Unknown

RECRUITING

Union Hospital Tongji Medical College Huazhong University of Science And Technology, Wuhan

RECRUITING

Zhejiang Provincial People's hospital, Hangzhou

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Akeso

INDUSTRY

NCT05859750 - A Study of AK104 With Chemotherapy as First-line Treatment in Patients With Advanced Pancreatic Cancer | Biotech Hunter | Biotech Hunter