A Study of MQ710 With and Without Pembrolizumab in People With Solid Tumor Cancer

PHASE1Active, not recruitingINTERVENTIONAL
Enrollment

5

Participants

Timeline

Start Date

May 4, 2023

Primary Completion Date

May 4, 2028

Study Completion Date

May 4, 2028

Conditions
Cutaneous Squamous Cell CarcinomaSCC - Squamous Cell CarcinomaBasal Cell CarcinomaBCCBCC - Basal Cell CarcinomaMelanomaMerkel Cell CarcinomaSebaceous CarcinomaExtramammary Paget DiseaseKaposi SarcomaHead and Neck Squamous Cell CarcinomaHNSCCAdnexal CarcinomaAngiosarcomaCutaneous NeoplasmAdvanced CancerMetastatic CancerRefractory CancerSolid Tumor
Interventions
BIOLOGICAL

MQ719

Patients will receive either multidose monotherapy with MQ710 or multidose combination therapy with MQ710 and pembrolizumab. The applicable dose of MQ710 will be injected directly into the patient's tumor (intratumorally), and standard dosing of pembrolizumab (200 mg) will be administered intravenously at a 3-week interval.

DRUG

Pembrolizumab

Patients will receive either multidose monotherapy with MQ710 or multidose combination therapy with MQ710 and pembrolizumab. The applicable dose of MQ710 will be injected directly into the patient's tumor (intratumorally), and standard dosing of pembrolizumab (200 mg) will be administered intravenously at a 3-week interval.

Trial Locations (7)

10065

Memorial Sloan Kettering Cancer Center (All Protocol Activities), New York

10604

Memorial Sloan Kettering Westchester (Limited Protocol Activities), Harrison

11553

Memorial Sloan Kettering Nassau (Limited Protocol Activities), Uniondale

11725

Memorial Sloan Kettering Suffolk-Commack (Limited Protocol Activities), Commack

07920

Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities), Basking Ridge

07748

Memorial Sloan Kettering Monmouth (Limited protocol activities), Middletown

07645

Memorial Sloan Kettering Bergen (Limited Protocol Activities), Montvale

All Listed Sponsors
lead

Memorial Sloan Kettering Cancer Center

OTHER