Durvalumab Plus Etoposide-free Chemotherapy in First-line Treatment of Extensive-disease Small-sell Lung Cancer (SCLC)

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

67

Participants

Timeline

Start Date

November 17, 2023

Primary Completion Date

February 28, 2026

Study Completion Date

February 29, 2028

Conditions
Small Cell Lung Cancer Extensive Stage
Interventions
DRUG

Carboplatin + Paclitaxel + Durvalumab

Carboplatin AUC 6, day 1 of three-week cycle for four cycles Paclitaxel 200 mg/m² day 1 of a three-week cycle for four cycles Durvalumab 1500 mg every 3 weeks for 4 cycles followed by 1500 mg maintenance every 4 weeks until progression, unacceptable toxicity, or consent withdrawal

Trial Locations (31)

14000

Caen - CHU Côte de Nacre, Caen

31059

CHU Toulouse, Toulouse

34295

CHU Montpellier, Montpellier

67091

Nouvel Hôpital Civil - Hôpitaux Universitaires de Strasbourg, Strasbourg

Unknown

Abbeville - CH, Abbeville

Amiens - Clinique de l'Europe, Amiens

Angers - CHU, Angers

Besançon - CHU, Besançon

Bordeaux - CHU, Bordeaux

Boulogne - Ambroise Paré, Boulogne-Billancourt

Chambéry - CH, Chambéry

Cholet - CH, Cholet

Colmar - CH, Colmar

Annemasse - CH, Contamine-sur-Arve

Créteil - CHI, Créteil

Dijon - CHU Bocage, Dijon

Grenoble - CHU, Grenoble

Le Mans - CHG, Le Mans

Lyon - URCOT, Lyon

Marseille - APHM, Marseille

Marseille - Hôpital Européen, Marseille

Morlaix - CH, Morlaix

Orléans - CHR, Orléans

Paris - Bichat, Paris

Paris - Hôpital Cochin, Paris

Paris - Tenon, Paris

Rennes - CHU, Rennes

Toulon - Sainte Anne HIA, Toulon

Tours - CHU, Tours

Vandoeuvre-lès-Nancy - CRLCC, Vandœuvre-lès-Nancy

Villefranche sur Saône - CH, Villefranche-sur-Saône

All Listed Sponsors
lead

Intergroupe Francophone de Cancerologie Thoracique

OTHER

NCT05856695 - Durvalumab Plus Etoposide-free Chemotherapy in First-line Treatment of Extensive-disease Small-sell Lung Cancer (SCLC) | Biotech Hunter | Biotech Hunter