Study of SAR447537 (INBRX-101) Compared to Plasma-derived A1PI Therapy in Adults With AATD Emphysema

PHASE2CompletedINTERVENTIONAL
Enrollment

99

Participants

Timeline

Start Date

October 12, 2023

Primary Completion Date

August 6, 2025

Study Completion Date

August 6, 2025

Conditions
Alpha 1-Antitrypsin DeficiencyEmphysema
Interventions
DRUG

SAR447537

A1PI, Recombinant, Bivalent Fc Fusion Protein

DRUG

Zemaira

Alpha1-Proteinase Inhibitor (Human)

Trial Locations (65)

1051

NZRSI, Greenlane

Investigational Site Number : 403, Auckland

2650

Donna McIntyre, Brisbane

2900

Investigational Site Number : 701, Hellerup

3065

Investigational Site Number : 203, Fitzroy

3128

Eastern Health Clinical School, Box Hill

3199

Frankston Hospital, Frankston

4032

Investigational Site Number : 202, Chermside

5000

Investigational Site Number : 201, Adelaide

5065

Royal Adelaide Hospital, North Adelaide

6009

Institute for Respiratory Health, Nedlands

Investigational Site Number : 206, Nedlands

6021

Investigational Site Number : 404, Wellington

P3 Research, Wellington

7100

Investigational Site Number : 702, Vejle

10032

Columbia University Irving Medical Center- Site Number : 104, New York

15706

Investigational Site Number : 903, Santiago de Compostela

17033

Penn State Health Milton S. Hershey Medical Center, Hershey

19140

Temple University Hospital- Site Number : 130, Philadelphia

Temple University Hospital, Philadelphia

29303

Velocity Clinical Research - Spartanburg - PPDS, Spartanburg

32610

University of Florida College of Medicine- Site Number : 101, Gainesville

University of Florida, Gainesville

33136

University of Miami, Miami

33607

Pulmonary and Sleep of Tampa Bay, Tampa

35249

University of Alabama at Birmingham, Birmingham

39008

Investigational Site Number : 901, Santander

60153

Loyola University Medical Center- Site Number : 112, Maywood

Loyola University Medical Center, Maywood

63401

Hannibal Clinic, Hannibal

77030

Houston Methodist Hospital- Site Number : 113, Houston

Houston Methodist Hospital, Houston

80206

National Jewish Medical and Research Center, Denver

84108

University of Utah Health, Salt Lake City

90095

David Geffen School of Medicine, Los Angeles

95817

UC Davis Comprehensive Cancer Center- Site Number : 110, Sacramento

UC Davis Medical Center, Sacramento

97239

Oregon Health and Science University- Site Number : 117, Portland

Oregon Health and Science University, Portland

35233-2110

University of Alabama at Birmingham- Site Number : 105, Birmingham

85013-4220

St Joseph's Hospital and Medical Center- Site Number : 126, Phoenix

St Joseph's Hospital and Medical Center, Phoenix

90095-3075

David Geffen School of Medicine- Site Number : 124, Los Angeles

80206-2761

National Jewish Medical and Research Center- Site Number : 123, Denver

06810

Western Connecticut Medical Group, Danbury

33125-1624

Bruce W. Carter Miami VA Medical Center - NAVREF - PPDS- Site Number : 114, Miami

33607-6316

Pulmonary and Sleep of Tampa Bay- Site Number : 115, Tampa

46202-5128

Indiana University, Indianapolis

55455-4800

M Health Fairview Clinics and Surgery Center - Minneapolis- Site Number : 125, Minneapolis

M Health Fairview Clinics and Surgery Center - Minneapolis, Minneapolis

63401-6890

Hannibal Regional Healthcare System-HRMG-Hannibal- Site Number : 111, Hannibal

15801-2277

Clinical Research Associates Of Central PA , LLC- Site Number : 128, DuBois

Clinical Research Associates Of Central PA , LLC, DuBois

17033-2360

Penn State Health Milton S. Hershey Medical Center- Site Number : 122, Hershey

29303-4225

Velocity Clinical Research - Spartanburg - PPDS- Site Number : 120, Spartanburg

84132-0001

University of Utah Health Care- Site Number : 106, Salt Lake City

Unknown

Queensland Centre for Pulmonary Transplantation, Chermside

St Vincent Hospital Melbourne, Fitzroy

01-138

Investigational Site Number : 801, Warsaw

30-688

Investigational Site Number : 802, Krakow

413 46

Investigational Site Number : 601, Gothenburg

DD1 9SY

Ninewells Hospital - PPDS, Dundee

M23 9QZ

Investigational Site Number : 306, Wythenshawe

Medicines Evaluation Unit, Manchester

B15 2WB

Investigational Site Number : 302, Birmingham

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Sanofi

INDUSTRY

NCT05856331 - Study of SAR447537 (INBRX-101) Compared to Plasma-derived A1PI Therapy in Adults With AATD Emphysema | Biotech Hunter | Biotech Hunter