Study of Chemosensory Enhancement Through Neuromodulation Training (SCENT for Long COVID)

PHASE2/PHASE3RecruitingINTERVENTIONAL
Enrollment

180

Participants

Timeline

Start Date

October 2, 2023

Primary Completion Date

May 31, 2028

Study Completion Date

May 31, 2028

Conditions
Smell DysfunctionOlfactory DisorderLong COVID
Interventions
DEVICE

Trigeminal Nerve Stimulation (TNS)

Non-invasive, pain-free, low-level electrical stimulation to the forehead to modulate the trigeminal nerve and enhance smell function through activation of the highly connected olfactory-intranasal trigeminal brain circuits.

OTHER

Active Smell Training (ST)

Sniffing various higher intensity odorant chemicals while performing odor-related cognitive tasks. 16 odorant chemicals will be used for training including: 2 phenyl ethanol, eugenol, lemon, eucalyptus, cinnamon, peppermint, coffee, mandarin, lavender, vanilla, lilac, ginger, chocolate, thyme, banana, and bacon.

OTHER

Placebo Smell Training (PBO)

Sniffing the same lower intensity odorant chemicals (i.e. N-butanol and 2-phenyl ethanol) over the course of the trial and performing no odor-related cognitive tasks.

Trial Locations (1)

29425

RECRUITING

Medical University of South Carolina, Charleston

All Listed Sponsors
collaborator

National Institutes of Health (NIH)

NIH

collaborator

National Institute on Deafness and Other Communication Disorders (NIDCD)

NIH

lead

Medical University of South Carolina

OTHER