180
Participants
Start Date
October 2, 2023
Primary Completion Date
May 31, 2028
Study Completion Date
May 31, 2028
Trigeminal Nerve Stimulation (TNS)
Non-invasive, pain-free, low-level electrical stimulation to the forehead to modulate the trigeminal nerve and enhance smell function through activation of the highly connected olfactory-intranasal trigeminal brain circuits.
Active Smell Training (ST)
Sniffing various higher intensity odorant chemicals while performing odor-related cognitive tasks. 16 odorant chemicals will be used for training including: 2 phenyl ethanol, eugenol, lemon, eucalyptus, cinnamon, peppermint, coffee, mandarin, lavender, vanilla, lilac, ginger, chocolate, thyme, banana, and bacon.
Placebo Smell Training (PBO)
Sniffing the same lower intensity odorant chemicals (i.e. N-butanol and 2-phenyl ethanol) over the course of the trial and performing no odor-related cognitive tasks.
RECRUITING
Medical University of South Carolina, Charleston
National Institutes of Health (NIH)
NIH
National Institute on Deafness and Other Communication Disorders (NIDCD)
NIH
Medical University of South Carolina
OTHER