700
Participants
Start Date
February 26, 2024
Primary Completion Date
April 1, 2028
Study Completion Date
April 1, 2029
Sat75
As per the current NRP guidelines, resuscitation will be initiated with 0.3 FiO2. FiO2 will be titrated every 30 seconds by 0.2-0.3 to achieve target SpO2 that approximates the 75th percentile SpO2 observed in healthy term newborns. Percentiles are roughly based on Dawson reference curves of healthy term infants after birth. Apart from the randomly assigned target SpO2, resuscitation will follow the current NRP guidelines. Following NICU admission, all care decisions, including ventilator management, will be at the discretion of the clinical team.
Sat50
As per the current NRP guidelines, resuscitation will be initiated with 0.3 FiO2. FiO2 will be titrated every 30 seconds by 0.1-0.2 to achieve target SpO2 that approximates the 50th percentile SpO2 observed in healthy term newborns. Percentiles are roughly based on Dawson reference curves of healthy term infants after birth. Apart from the randomly assigned target SpO2, resuscitation will follow the current NRP guidelines. Following NICU admission, all care decisions, including ventilator management, will be at the discretion of the clinical team.
RECRUITING
University of Texas Southwestern Medical Center, Dallas
University of Alabama at Birmingham
OTHER
University of Oklahoma
OTHER
North Central Baptist Hospital
UNKNOWN
Sharp Mary Birch Hospital for Women & Newborns
OTHER
The Woman's Hospital of Texas
OTHER
Baylor College of Medicine
OTHER
University of Florida Health
OTHER
University of Pittsburgh Medical Center
OTHER
University of Pittsburgh
OTHER
University of Utah
OTHER
Primary Children's Hospital
OTHER
Methodist Children's Hospital
UNKNOWN
University of Texas Southwestern Medical Center
OTHER