90
Participants
Start Date
November 3, 2023
Primary Completion Date
December 31, 2028
Study Completion Date
December 31, 2033
Dexamethasone
Given orally (PO) or naso-gastrically (NG) or intravenously (IV).
Mitoxantrone
Given IV
PEG asparaginase
Given IV
Bortezomib
Given IV
Vorinostat
Taken PO or NG
Mercaptopurine
Given PO or NG.
Methotrexate
Given IV, IM or PO
Blinatumomab
Will be administered at 15 mcg/m2/day for 28 days following induction and reinduction
Ziftomenib
3+3 dose escalation will be done. Dose level 1 will start at 75% of the adult recommended phase two dosing which has been established in phase I studies. Based on tolerability, we will either de-escalate to 50% RP2D (dose level -1) or escalate to 100% RP2D
RECRUITING
Memorial Sloan Kettering Cancer Center, New York
RECRUITING
Children's Hospital of The King's Daughters, Norfolk
NOT_YET_RECRUITING
Novant Health - Hemby Children's Hospital, Charlotte
NOT_YET_RECRUITING
Arnold Palmer Hospital for Children, Orlando
NOT_YET_RECRUITING
University of Wisconsin Carbone Cancer Center, Madison
RECRUITING
Children's Hospital of Minnesota, Minneapolis
RECRUITING
Arkansas Children's Hospital, Little Rock
RECRUITING
MD Anderson, Houston
RECRUITING
University of Texas Health Science Center San Antonio, San Antonio
NOT_YET_RECRUITING
University of Utah Huntsman Cancer Institute, Salt Lake City
NOT_YET_RECRUITING
Phoenix Children's Hospital, Phoenix
NOT_YET_RECRUITING
Children's Hospital Los Angeles, Los Angeles
NOT_YET_RECRUITING
Rady Children's Hospital San Diego, San Diego
NOT_YET_RECRUITING
Children's Hospital of Orange County, Orange
NOT_YET_RECRUITING
Valley Children's Hospital, Madera
RECRUITING
Stanford University, Palo Alto
NOT_YET_RECRUITING
Doernbecher Children's Hospital, Portland
NOT_YET_RECRUITING
Penn State Milton S Hershey Medical Center, Hershey
NOT_YET_RECRUITING
Alberta Children's Hospital, Calgary
NOT_YET_RECRUITING
Stollery Children's Hospital, Edmonton
NOT_YET_RECRUITING
BC Children's Hospital, Vancouver
NOT_YET_RECRUITING
McMaster Children's Hospital, Hamilton
NOT_YET_RECRUITING
CHU Sainte-Justine, Montreal
NOT_YET_RECRUITING
Montreal Children's Hospital, Montreal
NOT_YET_RECRUITING
Chu De Quebec, Québec
Collaborators (2)
Pediatric Oncology Experimental Therapeutics Investigators' Consortium
UNKNOWN
Amgen
INDUSTRY
Lucile Packard Foundation for Children's Health
UNKNOWN
Kura Oncology, Inc.
INDUSTRY
Tanja Andrea Gruber
OTHER