A Study of Lorigerlimab With Docetaxel or Docetaxel Alone in Participants With Metastatic Castration-Resistant Prostate Cancer

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

154

Participants

Timeline

Start Date

September 28, 2023

Primary Completion Date

September 30, 2026

Study Completion Date

September 30, 2027

Conditions
Androgen-Independent Prostatic CancerAndrogen-Independent Prostatic NeoplasmsProstate Cancer RecurrentAndrogen-Insensitive Prostatic CanceAndrogen-Resistant Prostatic CancerHormone Refractory Prostatic CancerImmunotherapyImmune Checkpoint InhibitorInhibitory Checkpoint Molecule
Interventions
BIOLOGICAL

lorigerlimab

Lorigerlimab is a DART® molecule that binds PD-1 and CTLA-4

DRUG

docetaxel

Docetaxel Injection is a cytotoxic anticancer drug approved to treat prostate cancer

DRUG

Prednisone

A corticosteroid drug approved for use with docetaxel in the treatment of prostate cancer

Trial Locations (51)

10029

Icahn School of Medicine at Mount Sinai, New York

22903

University of Virginia Health System Cancer Center, Charlottesville

32806

Orlando Health Cancer Institute, Orlando

33135

United Medical Group, Miami

68803

Nebraska Cancer Specialists, Grand Island

77030

MD Anderson Cancer Center, Houston

02215

Beth Israel Deaconess Medical Center, Boston

Dana-Farber Cancer Institute, Boston

Unknown

Peter MacCallum Cancer Centre, North Melbourne

North Shore Private Hospital, St Leonards

Westmead Hospital, Westmead

Cliniques universitaires Saint-Luc (CUSL), Brussels, Brussels

UZ GENT, Ghent

Centre Hospital de l'Ardenne, Libramont

Comprehensive Cancer Center, Plovdiv

UMHAT Sv. Ivan Rilski, Sofia

Institut Bergonie, Bordeaux

Clinique Victor Hugo, Le Mans

Centre Léon Bérard, Lyon

Centre Antoine Lacassagne, Nice

Institut Mutualiste Montsouris, Paris

Centre Hospitalier Quimper, Quimper

CHP Saint Grégoire, Saint-Grégoire

Hia Begin, Saint-Mandé

Hopital Foch, Suresnes

LTD High Tech Hosp Medcenter, Batumi

First University Clinic TSMU, Tbilisi

LTD Consilium Medulla, Tbilisi

Ltd Gidmedi, Tbilisi

LtD L.M.National Urology Center, Tbilisi

LTD MMT Hospital, Tbilisi

LTD Todua Clinic, Tbilisi

Onc. Scient. Research Center, Tbilisi

Przychodnia Lekarska KOMED, Konin

Pratia McM Kraków, Krakow

Europejskie Centrum Zdrowia Otwock, Szpital im. Fryderyka Chopina, Otwock

Szpital Grochowski im. dr med. Rafała Masztaka Sp. z o.o., Oddział Chemioterapii, Warsaw

Pan American Center for Oncology Trials, LLC, Rio Piedras

H U Germans Tries i Pujol, Barcelona

Hospital Clínic de Barcelona, Barcelona

Hospital del Mar, Barcelona

Hospital Sant Pau, Barcelona

Institut Català d'Oncologia Hospitalet_ICO Hospitalet, Barcelona

Vall d' Hebron Institute of Oncology (VHIO), Barcelona

Hospital 12 de octubre, Madrid

Hospital Universitario Virgen del Rocio, Seville

FIVO: Instituto Valenciano de Oncología, Valencia

Churchill Hospital, Headington

Charing Cross Hospital, London

Royal Marsden Hospital, Sutton

Musgrove Park Hospital, Taunton

Sponsors

Lead Sponsor

All Listed Sponsors
lead

MacroGenics

INDUSTRY