Intravitreal Faricimab Injections or Fluocinolone Acetonide (0.19 mg) Intravitreal Implants vs Observation for Prevention of VA Loss Due to Radiation Retinopathy

PHASE3RecruitingINTERVENTIONAL
Enrollment

600

Participants

Timeline

Start Date

November 21, 2023

Primary Completion Date

December 26, 2029

Study Completion Date

December 26, 2029

Conditions
Radiation RetinopathyVisual Impairment
Interventions
DRUG

Faricimab

6.0 mg intravitreal injection at randomization and every 3 months

DRUG

fluocinolone acetonide

0.19 mg fluocinolone acetonide intravitreal implant (Iluvien) at randomization and at 24 months

Trial Locations (19)

15146

RECRUITING

Retina-Vitreous Consultants, Inc., Monroeville

19107

RECRUITING

Wills Eye Hospital, Philadelphia

29605

RECRUITING

Retina Consultants of Carolina, PA, Greenville

33609

RECRUITING

Retina Associates of Florida, LLC, Tampa

37203

RECRUITING

Tennessee Retina, PC, Nashville

44120

RECRUITING

The Cleveland Clinic Foundation DBA Cleveland Clinic Lerner College of Medicine, Cleveland

46290

RECRUITING

Midwest Eye Institute, Indianapolis

48073

RECRUITING

Associated Retinal Consultants, P.C., Royal Oak

49546

RECRUITING

Foundation for Vision Research and Retina Specialists of Michigan, P.C., Grand Rapids

52242

RECRUITING

University of Iowa Department of Ophthalmology and Visual Sciences, Iowa City

53705

RECRUITING

The Board of Regents of the University of Wisconsin System, Madison

55905

RECRUITING

Mayo Clinic, Rochester

60612

RECRUITING

IL Eye and Ear Infirmary-University of Illinois at Chicago, Chicago

63128

RECRUITING

Retina Research Institute, LLC, St Louis

77401

RECRUITING

Retina Consultants of Texas, PA, Bellaire

79424

RECRUITING

Texas Retina Associates, Lubbock

94303

RECRUITING

Byers Eye Institute at Stanford University, Palo Alto

97239

RECRUITING

Oregon Health & Science University, Portland

06042

RECRUITING

Retina Consultants, Manchester

All Listed Sponsors
collaborator

National Eye Institute (NEI)

NIH

collaborator

National Institutes of Health (NIH)

NIH

collaborator

Alimera Sciences

INDUSTRY

collaborator

Genentech, Inc.

INDUSTRY

lead

Jaeb Center for Health Research

OTHER