Short-term Sintilimab in Combination With Taxane and Carboplatin for Neoadjuvant Therapy in Triple-negative Breast Cancer

PHASE4Not yet recruitingINTERVENTIONAL
Enrollment

48

Participants

Timeline

Start Date

July 1, 2023

Primary Completion Date

December 31, 2024

Study Completion Date

December 31, 2034

Conditions
Triple-negative Breast Cancer
Interventions
DRUG

Taxane and Carboplatin

"Nab-paclitaxel 100mg/m2+ Carboplatin AUC2 by intravenous (IV) infusion on day1, day8 and day15, every 4 weeks, for 4 cycles.~or Docetaxel 75mg/m2+ Carboplatin AUC5 by intravenous (IV) infusion on day1, every 3 weeks, for 4 cycles.~or Paclitaxel 80mg/m2+ Carboplatin AUC2 by intravenous (IV) infusion on day1, day8 and day15, every 4 weeks, for 4 cycles."

DRUG

Short-term Sintilimab

Sintilimab 200mg by intravenous (IV) infusion on day1, every 3 weeks, for 2 cycles.

PROCEDURE

Surgery

All participants who are eligible for surgery will undergo surgery and have their pathologic response evaluated.

All Listed Sponsors
collaborator

Innovent Biologics, Inc.

OTHER

collaborator

CSPC Ouyi Pharmaceutical Co., Ltd.

INDUSTRY

lead

Shanghai Jiao Tong University School of Medicine

OTHER

NCT05843292 - Short-term Sintilimab in Combination With Taxane and Carboplatin for Neoadjuvant Therapy in Triple-negative Breast Cancer | Biotech Hunter | Biotech Hunter