Lenvatinib Plus Tislelizumab With or Without TACE in First-line Treatment of Unresectable HCC

PHASE1/PHASE2RecruitingINTERVENTIONAL
Enrollment

60

Participants

Timeline

Start Date

September 1, 2022

Primary Completion Date

April 15, 2024

Study Completion Date

November 15, 2024

Conditions
Hepatocellular Carcinoma
Interventions
DRUG

Lenvatinib Plus Tislelizumab

Lenvatinib is 12mg/d for body weight \>= 60kg, 8mg/d for body weight \<60kg, once daily orally, once a day, after meals (take at the same time every day as much as possible); Tislelizumab is administered intravenously at a dose of 200mg/q3w.

DEVICE

Transarterial Chemoembolization(TACE)

A catheter is inserted through a small incision in the groin and guided to the hepatic artery, which supplies blood to the liver;A contrast dye is injected through the catheter to help visualize the blood vessels in the liver; A mixture of chemotherapy drugs and an embolic agent (such as small beads or gel foam) is injected through the catheter and into the artery that feeds the tumor;The embolic agent helps to block the blood flow to the tumor, which starves it of oxygen and nutrients; The chemotherapy drugs are then trapped in the tumor.

Trial Locations (1)

100730

RECRUITING

Nan Zhang, Beijing

All Listed Sponsors
lead

Peking Union Medical College Hospital

OTHER