Subclinical Hypothyroidism and Chronic Inflammation in PCOS

NACompletedINTERVENTIONAL
Enrollment

158

Participants

Timeline

Start Date

January 1, 2024

Primary Completion Date

December 30, 2024

Study Completion Date

December 30, 2024

Conditions
PCOS (Polycystic Ovary Syndrome) of Bilateral OvariesSubclinical hypothyroïdismHypothalamic-Pituitary-Gonadal Axis Dysfunction
Interventions
DIAGNOSTIC_TEST

Measurement and comparison of leucocytosis and concentrations of CRP, procalcitonin, fibrinogen, ferritin, IL-1, IL-6, IL-10, TNF-alpha in both study arms

A venous blood sample of approximately 10 ml will be collected in the morning after 8 hours of fasting to determine and compare the above parameters of peripheral blood in both arms of the study

DIAGNOSTIC_TEST

Evaluation of the impact of subclinical hypothyroidism, with present/ absent antithyroid antibodies, on the balance between anti- and pro-inflammatory factors in women in both study arms

A venous blood sample of approximately 10 ml will be collected in the morning after 8 hours of fasting to determine and compare blood levels of leukocytosis, CRP, procalcitonin, fibrinogen, ferritin, IL-1, IL-6, IL-10, TNF-alpha depending on the blood concentrations of TSH, a-TPO and a-TG in women in both study arms

DIAGNOSTIC_TEST

Assessment of the impact of imbalance between anti- and pro-inflammatory factors in women with different PCOS and HPOD phenotypes on ovarian reserve indices

A venous blood sample of approximately 10 ml will be collected in the morning after 8 hours of fasting to determine and compare blood levels of leukocytosis, CRP, procalcitonin, fibrinogen, ferritin, IL-1, IL-6, IL-10, TNF-alpha and AMH, FSH in women in both study arms

Trial Locations (1)

31-501

Jagiellonian University Medical College, Department of Gynecology and Obstetrics, Krakow

All Listed Sponsors
lead

Jagiellonian University

OTHER

NCT05842096 - Subclinical Hypothyroidism and Chronic Inflammation in PCOS | Biotech Hunter | Biotech Hunter