40
Participants
Start Date
June 20, 2023
Primary Completion Date
July 31, 2025
Study Completion Date
December 31, 2025
Magstim Rapid2
"1-4 weeks after administration of the SJI, participants will attend their first rTMS session. rTMS will be delivered using a biphasic stimulator (DuoMag) and a figure-of-eight coil to the corticomotor representation of the first dorsal interosseous muscle contralateral to the side of worst pain. Recording electrodes will be positioned in a belly-tendon montage over the FDI for electromyography recording. The hotspot and resting motor threshold (rMT) of the FDI will be determined and saved using a Brainsight Neuronavigation system to ensure accurate coil repositioning within and between sessions.~The hotspot and rMT will be confirmed and adjusted if needed at each intervention session. Each rTMS session will consist of 40 trains of 5s delivered at 10Hz, at an intensity of 85% of the resting motor threshold for the FDI muscle and an intertrain interval of 25s (total of 2000 stimulations in a 20-minute session)."
Placebo D70mm Air Film Coil
Sham intervention will follow same protocol as active rTMS using a sham coil that does not deliver actual magnetic stimulation.
RECRUITING
St. Joseph's Health Care London, London
RECRUITING
Parkwood Institute (Main Building), London
Western University, Canada
OTHER
St. Joseph's Health Care London
OTHER
London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
OTHER